期刊
MICROMACHINES
卷 12, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/mi12121464
关键词
SARS-CoV-2 variants; detection; epidemic; point of care testing
类别
资金
- Romanian Ministry of Research, Innovation and Digitalization, CCCDI-UEFISCDI [PN-III-P2-2.1-SOL-2020-0090-Contract 13Sol/15.06.2020, PNIII-P4-ID-PCE-2020-186, PCE 180/17/02/2021, CNFIS-FDI-2021-0405]
This article summarizes and compares available strategies for COVID-19 diagnosis, including serological testing, Point-of-Care Testing, nanotechnology-based approaches and biosensors. It addresses the advantages and limitations of these methods, as well as the prospects for COVID-19 diagnostics.
The deleterious effects of the coronavirus disease 2019 (COVID-19) pandemic urged the development of diagnostic tools to manage the spread of disease. Currently, the gold standard involves the use of quantitative real-time polymerase chain reaction (qRT-PCR) for SARS-CoV-2 detection. Even though it is sensitive, specific and applicable for large batches of samples, qRT-PCR is labour-intensive, time-consuming, requires trained personnel and is not available in remote settings. This review summarizes and compares the available strategies for COVID-19: serological testing, Point-of-Care Testing, nanotechnology-based approaches and biosensors. Last but not least, we address the advantages and limitations of these methods as well as perspectives in COVID-19 diagnostics. The effort is constantly focused on understanding the quickly changing landscape of available diagnostic testing of COVID-19 at the clinical levels and introducing reliable and rapid screening point of care testing. The last approach is key to aid the clinical decision-making process for infection control, enhancing an appropriate treatment strategy and prompt isolation of asymptomatic/mild cases. As a viable alternative, Point-of-Care Testing (POCT) is typically low-cost and user-friendly, hence harbouring tremendous potential for rapid COVID-19 diagnosis.
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