期刊
MICROMACHINES
卷 12, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/mi12121542
关键词
microfluidics; organ-on-a-chip; assembly; configurable
A low-cost, versatile, and reconfigurable fluidic routing system and chip assembly have been developed, showcasing the custom design of chip-to-chip communication and versatility for various biological models.
A low-cost, versatile, and reconfigurable fluidic routing system and chip assembly have been fabricated and tested. The platform and its accessories were fabricated in-house without the need for costly and specialized equipment nor specific expertise. An agarose-based artificial membrane was integrated into the chips and employed to test the chip-to-chip communication in various configurations. Various chip assemblies were constructed and tested which demonstrate the versatile utility of the fluidic routing system that enables the custom design of the chip-to-chip communication and the possibility of fitting a variety of (organ-on-a-chip)-based biological models with multicell architectures. The reconfigurable chip assembly would enable selective linking/isolating the desired chip/compartment, hence allowing the study of the contribution of specific cell/tissue within the in vitro models.
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