期刊
MICROMACHINES
卷 12, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/mi12101162
关键词
red blood cells; axial migration; lattice-Boltzmann method; finite element method; immersed boundary method; computational biomechanics
类别
资金
- JSPS KAKENHI [JP20H04504, JP20H02072]
- Keihanshin Consortium for Fostering the Next Generation of Global Leaders in Research (K-CONNEX)
- Human Resource Development Program for Science and Technology
- UCL-Osaka Partner Funds
This study numerically investigated the behavior of single red blood cells in a circular microchannel, revealing that the axial or nonaxial migration of red blood cells depends on their stable deformed shapes, and the equilibrium radial position of the red blood cell centroid correlates well with energy expenditure associated with membrane deformations.
Human red blood cells (RBCs) are subjected to high viscous shear stress, especially during microcirculation, resulting in stable deformed shapes such as parachute or slipper shape. Those unique deformed RBC shapes, accompanied with axial or nonaxial migration, cannot be fully described according to traditional knowledge about lateral movement of deformable spherical particles. Although several experimental and numerical studies have investigated RBC behavior in microchannels with similar diameters as RBCs, the detailed mechanical characteristics of RBC lateral movement-in particular, regarding the relationship between stable deformed shapes, equilibrium radial RBC position, and membrane load-has not yet been fully described. Thus, we numerically investigated the behavior of single RBCs with radii of 4 mu m in a circular microchannel with diameters of 15 mu m. Flow was assumed to be almost inertialess. The problem was characterized by the capillary number, which is the ratio between fluid viscous force and membrane elastic force. The power (or energy dissipation) associated with membrane deformations was introduced to quantify the state of membrane loads. Simulations were performed with different capillary numbers, viscosity ratios of the internal to external fluids of RBCs, and initial RBC centroid positions. Our numerical results demonstrated that axial or nonaxial migration of RBC depended on the stable deformed RBC shapes, and the equilibrium radial position of the RBC centroid correlated well with energy expenditure associated with membrane deformations.
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