Bimetallic Nanomaterials-Based Electrochemical Biosensor Platforms for Clinical Applications

Diabetes is a foremost health issue that results in ~4 million deaths every year and ~170 million people suffering globally. Though there is no treatment for diabetes yet, the blood glucose level of diabetic patients should be checked closely to avoid further problems. Screening glucose in blood has become a vital requirement, and thus the fabrication of advanced and sensitive blood sugar detection methodologies for clinical analysis and individual care. Bimetallic nanoparticles (BMNPs) are nanosized structures that are of rising interest in many clinical applications. Although their fabrication shares characteristics with physicochemical methodologies for the synthesis of corresponding mono-metallic counterparts, they can display several interesting new properties and applications as a significance of the synergetic effect between their two components. These applications can be as diverse as clinical diagnostics, anti-bacterial/anti-cancer treatments or biological imaging analyses, and drug delivery. However, the exploitation of BMNPs in such fields has received a small amount of attention predominantly due to the vital lack of understanding and concerns mainly on the usage of other nanostructured materials, such as stability and bio-degradability over extended-time, ability to form clusters, chemical reactivity, and biocompatibility. In this review article, a close look at bimetallic nanomaterial based glucose biosensing approaches is discussed, concentrating on their clinical applications as detection of glucose in various real sample sources, showing substantial development of their features related to corresponding monometallic counterparts and other existing used nanomaterials for clinical applications.

Automated summary

Diabetes is a major global health issue causing significant deaths and suffering. The development of advanced and sensitive blood sugar detection methods is crucial for managing diabetes. Bimetallic nanoparticles have potential clinical applications in various fields, but their utilization has been limited due to concerns about stability, bio-degradability, cluster formation, chemical reactivity, and biocompatibility. This review focuses on bimetallic nanomaterial-based glucose biosensing approaches and their substantial development compared to monometallic counterparts and other nanomaterials used in clinical applications.