期刊
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
卷 28, 期 1, 页码 78-85出版社
KOREAN SOC NEUROGASTROENTEROLOGY & MOTILITY
DOI: 10.5056/jnm20231
关键词
Adolescent; Child; Functional abdominal pain disorders; Glucose breath test; Small intestinal bacterial overgrowth
资金
- Korean Society of Pediatric Infectious Diseases
Small intestinal bacterial overgrowth (SIBO) is not uncommon in children and adolescents with functional abdominal pain disorders (FAPDs). Age (≥12 years) and loose stool were significantly more common in children with SIBO, while the history of allergies was less common in this group. Further studies are needed to investigate the association between intestinal bacteria and history of allergy.
Background/Aims Small intestinal bacterial overgrowth (SIBO) is expected in children and adolescents with functional abdominal pain disorders (FAPDs). This study is conducted to estimate the prevalence of SIBO and to investigate the role of SIBO in children and adolescents with FAPDs. Methods This prospective study enrolled children with FAPDs fulfilling the Rome IV criteria. A hydrogen-methane glucose breath test was used to diagnose SIBO. A survey of bowel symptoms using questionnaires, birth history, types of feeding, and the presence of allergy was conducted. Results Sixty-eight children and adolescents (range, 6-17 years; median, 12.5 years) were enrolled. SIBO was detected in 14 patients (20.6%). Age (>_ 12 years) (P < 0.003) and loose stool (P = 0.048) were significantly more common in children with SIBO than in children without SIBO. However, the history of allergies (P = 0.031) was less common in children with SIBO than those without SIBO. No significant differences were observed in other demographic findings. In multivariate analysis, age (>_ 12 years) was the independent factor predicting SIBO in children with FAPDs. Conclusions SIBO is not uncommon in children and adolescents with FAPDs. Among children aged above 12 years and diagnosed with FAPDs, SIBO is a suspected clinical target for treatment to relieve intestinal symptoms. A further study to investigate the association between intestinal bacteria and history of allergy is needed. (J Neurogastroenterol Motil 2022;28:78-85)
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