期刊
JOURNAL OF NANOBIOTECHNOLOGY
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12951-021-01134-6
关键词
Pancreatic cancer; Tumor microenvironment; Nano-delivery systems; Cancer-associated fibroblasts; Extracellular matrix; Immunosuppression
资金
- Science and Technology Project of Luzhou Government [2019-JYJ-51]
Modulating the microenvironment of pancreatic cancer is considered a promising therapeutic approach, and nano-delivery systems have been developed to alter the TME. These systems change the microenvironment in various ways, including depleting ECM, inhibiting CAFs, reversing immunosuppression, promoting angiogenesis, and improving the hypoxic environment.
Pancreatic cancer is one of the most lethal malignant tumors with a low survival rate, partly because the tumor microenvironment (TME), which consists of extracellular matrix (ECM), cancer-associated fibroblasts (CAFs), immune cells, and vascular systems, prevents effective drug delivery and chemoradiotherapy. Thus, modulating the microenvironment of pancreatic cancer is considered a promising therapeutic approach. Since nanoparticles are one of the most effective cancer treatment strategies, several nano-delivery platforms have been developed to regulate the TME and enhance treatment. Here, we summarize the latest advances in nano-delivery systems that alter the TME in pancreatic cancer by depleting ECM, inhibiting CAFs, reversing immunosuppression, promoting angiogenesis, or improving the hypoxic environment. We also discuss promising new targets for such systems. This review is expected to improve our understanding of how to modulate the pancreatic cancer microenvironment and guide the development of new therapies.
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