期刊
JOURNAL OF MATERIALS CHEMISTRY C
卷 10, 期 2, 页码 688-695出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tc04930e
关键词
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资金
- Netherlands Organization for Scientific Research [731.015.206]
- TTW perspective project MEDPHOT, EU H2020-MSCA-ITN-ETN Action program, ISPIC [675743]
- EU H2020-MSCA-RISE-2017 Action program, CANCER [777682]
- National Science Fund of China [62105031]
- Beijing Institute of Technology Research Fund Program for Young Scholars
- Fundamental Research Funds for the Central Universities, JLU
The concept of upconversion luminescence image guided synergy of photodynamic therapy and radiotherapy for deep cancer treatment has been proposed and validated using a specially designed nanoplatform. This novel theranostic approach combines the advantages of different therapies to effectively destroy cancer cells and reduce X-ray dosage, showing great potential for deep cancer treatment in both in vitro and in vivo experiments.
Collaborative therapy is regarded as an effective approach in increasing the therapeutic efficacy of cancer. In this work, we have proposed and validated the concept of upconversion lumienscence image guided synergy of photodynamic therapy (PDT) and radiotherapy (RT) for deep cancer, via a specially designed nanoplatform integrating near infrared (NIR) light activated luminescence upconversion and X-ray induced scintillation. Upon NIR light irradiation, the nanoplatform emits highly monochromatic red light solely for imaging the targeted cancer cells without triggering therapy; however, when the irradiation turns to a low dose of X-rays, scintillation will occur which induces effectively the PDT destroying the cancer cells together with X-ray induced RT. The novel theranostic nanoplatform is constructed in such a way that the interactions between the upconversion core and the outmost scintillating shell are blocked effectively by an inert layer between them. This structural design not only enables a nearly perfect excitation energy delivery (similar to 100% at a spectral overlapping wavelength of similar to 540 nm) from the outermost scintellating layer to the surface-anchored photosensitizers and so a maximum yield of radical oxygen species, but also achieves a strong NIR induced upconversion luminescence for imaging. Since PDT and RT attack different parts of a cancer cell, this synergy is more effective in destroying cancer than a single therapy, resulting in the reduction of the X-ray irradiation dosage. As a proof of principle, the theranostic effect is validated by in vitro and in vivo experiments, exhibiting the great potential of this sort of nanoplatform in deep cancer treatment.
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