期刊
JOURNAL OF CANCER
卷 13, 期 4, 页码 1241-1251出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.62652
关键词
miR-497-5p; RSPO2; Oncogenesis; The Wnt/beta-catenin pathway; GBM
类别
资金
- Shandong Natural Science Foundation [ZR2020 KH026]
Numerous studies have found a relationship between cancer formation and aberrant microRNA expression. This study found that miR-497-5p expression was significantly lower in GBM tissues compared to normal brain glial cells. Mechanistic investigations revealed that miR-497-5p suppresses the Wnt/beta-catenin signaling pathway by targeting RSPO2, leading to reduced cell proliferation, migration, and invasion in GBM.
Numerous studies have found a relationship between cancer formation and aberrant microRNA expression, however the biological significance of miR-497-5p in glioblastoma (GBM) is still unknown. Compared to normal brain glial cells, miR-497-5p expression in GBM tissues was substantially lower in our study. The microRNA miR-497-5p targets R-spondin 2 (RSPO2) only when it is present. RSPO2 silencing has the same effect on GBM cells as miR-497-5p silencing, as demonstrated before. Additional mechanistic investigations have shown that miR-497-5p suppresses the Wnt/beta-catenin signaling pathway by targeting RSPO2 to reduce cell proliferation, migration, and invasion. A negative correlation was discovered between MiR-497-5p and RSPO2 in 37 of the GBM tumors studied. MiR-497-5p-RSPO2 axis controls Wnt/beta-catenin signaling and plays a function in GBM carcinogenesis, suggesting that it may be a therapeutic target to reduce GBM growth, as shown by our research findings.
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