期刊
JOURNAL OF CANCER
卷 13, 期 1, 页码 174-183出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.65031
关键词
LncRNAs; lung cancer; tumor biomarkers; MALAT1; and HOTAIR
类别
资金
- National Natural Science Foundation of China [81972636, 81872281, 81772842]
- Natural Science Foundation of Hunan Province [2020JJ5336, 2019JJ40175, 2019JJ40183, 2018JJ1013]
- Research Project of Health Commission of Hunan Province [20201020, B20180400, B20180582]
- China Hunan Provincial Science and Technology Department [2018SK7005]
- Ascend Foundation of National cancer center [NCC2018b68]
- Hunan Cancer Hospital Climb Plan
- Fundamental Research Funds for the Central Universities of Central South University [2019zzts832, 2019zzts833]
Lung cancer is a common and deadly malignancy with increasing incidence and mortality rates. Despite the development of new therapeutic methods, the overall survival rate of lung cancer remains low. Therefore, it is crucial to focus on molecular oncology to find novel biomarkers and targets for early diagnosis, treatment, and prognosis prediction of lung cancer. Long non-coding RNAs (lncRNAs) play important roles in lung cancer and have translational potential in clinical settings.
Lung cancer is the most common malignancy, being a serious threat of human lives. The incidence and mortality of lung cancer has been increasing rapidly in the past decades. Although the development of new therapeutic modes, such as target therapy, the overall survival rate of lung cancer remains low. It is urgent to advance the understanding of molecular oncology and find novel biomarkers and targets for the early diagnosis, treatment, and prognostic prediction of lung cancer. Long non-coding RNAs (lncRNAs) are non-protein coding RNA transcripts that are more than 200 nucleotides in length. LncRNAs exert diverse biological functions by regulating gene expressions at transcriptional, translational, and post-translational levels. In the past decade, it has been shown that lncRNAs are extensively involved in the pathogenesis of various diseases, including lung cancer. In this review, we highlighted the lncRNAs characterized in lung cancer and discussed their translational potential in lung cancer clinics.
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