期刊
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
卷 12, 期 6, 页码 2069-2078出版社
WILEY
DOI: 10.1002/jcsm.12810
关键词
Frailty; Disability; Trajectories; Older adults; Slowness
资金
- Brazilian fostering agency Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [Coordination for the Advancement of Higher Education Personnel (CAPES)] [001]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq (National Council of Scientific and Technological Development)] [303981/2017-2, 303577/2020-7]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP (State of Sao Paulo Research Assistance Foundation)] [18/13917-3]
- National Institute on Aging USA [R01AG017644]
- Economic and Social Research Council (ESRC)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [18/13917-3] Funding Source: FAPESP
This study analyzing the trajectory of incident disability in older adults found that women were more likely to develop disabilities in basic and instrumental activities of daily living after becoming frail, while men and women both had a higher risk of disability after becoming frail. Slowness was identified as a key warning sign for functional decline, particularly in men and women who also showed weakness, low physical activity levels, and exhaustion as contributing factors to disability.
Background The trajectory of incident disability that occurs simultaneously with changes in frailty status, as well as how much each frailty component contributes to this process in the different sexes, are unknown. The objective of this study is to analyse the trajectory of the incidence of disability on basic and instrumental activities of daily living (BADL and IADL) as a function of the frailty changes and their components by sex over time. Methods Longitudinal analyses of 1522 and 1548 of the English Longitudinal Study of Ageing study participants without BADL and IADL disability, respectively, and without frailty at baseline. BADL and IADL were assessed using the Katz and Lawton Scales and frailty by phenotype at 4, 8, and 12 years of follow-up. Generalized mixed linear models were calculated for the incidence of BADL and IADL disability, as an outcome, using changes in the state of frailty and its components, as the exposure, by sex in models fully adjusted for sociodemographic, behavioural, biochemical, and clinical characteristics. Results The mean age, at baseline, of the 1522 eligible individuals free of BADL and free of frailty was 68.1 +/- 6.2 years (52.1% women) and of the 1548 individuals free IADL and free frailty was 68.1 +/- 6.1 years (50.6% women). Women who became pre-frail had a higher risk of incidence of disability for BADL and IADL when compared with those who remained non-frail (P < 0.05). Men and women who became frail had a higher risk of incidence of disability regarding BADL and IADL when compared with those who remained non-frail (P < 0.05). Slowness was the only component capable of discriminating the incidence of disability regarding BADL and IADL when compared with those who remained without slowness (P < 0.05). Weakness and low physical activity level in men and exhaustion in women also discriminated the incidence of disability (P < 0.05). Conclusions Slowness is the main warning sign of functional decline in older adults. As its evaluation is easy, fast, and accessible, screening for this frailty component should be prioritized in different clinical contexts so that rehabilitation strategies can be developed to avoid the onset of disability.
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