期刊
JOURNAL OF THE AMERICAN HEART ASSOCIATION
卷 11, 期 1, 页码 -出版社
WILEY
DOI: 10.1161/JAHA.121.022607
关键词
acute ischemic stroke; growth differentiation factor 15; Hamilton rating scale for depression; poststroke depression
资金
- National Natural Science Foundation of China [82103917, 81803309, 82020108028]
- high-level personnel project of Jiangsu Province [JSSCBS20210712]
- Natural Science Research Project of Jiangsu Provincial Higher Education [21KJB330006]
- Startup Fund from Soochow University [Q413900420]
- Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJQN201800441]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
This study found that elevated serum GDF-15 levels in the acute phase of ischemic stroke were independently associated with PSD, suggesting that GDF-15 may be a valuable prognostic biomarker for PSD.
Background The effect of serum growth differentiation factor 15 (GDF-15) on poststroke depression (PSD) remains unknown. This study aimed to investigate the association between serum GDF-15 and PSD among patients with ischemic stroke. Methods and Results This study was based on a random sample from CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). A total of 572 patients from 7 participating hospitals with GDF-15 levels were included in this analysis. The study outcome was depression (Hamilton Depression Rating Scale score >= 8) at 3 months after ischemic stroke. A total of 231 (40.4%) patients with stroke experienced PSD within 3 months. The multivariate-adjusted odds ratio of PSD associated with the highest tertile of serum GDF-15 was 2.92 (95% CI, 1.36-6.27) compared with the lowest tertile. Each SD increase in log-transformed GDF-15 was associated with a 42% (95% CI, 2%-97%) increased risk of PSD, and a linear association between serum GDF-15 and the risk of PSD was observed (P for linearity=0.006). Conclusions Elevated serum GDF-15 levels in the acute phase of ischemic stroke were independently associated with PSD, suggesting that GDF-15 may be a valuable prognostic biomarker for PSD.
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