4.6 Article

Panax notoginseng Saponin Protects Against Diabetic Cardiomyopathy Through Lipid Metabolism Modulation

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Cardioprotection of Panax Notoginseng saponins against acute myocardial infarction and heart failure through inducing autophagy

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Summary: Panax Notoginseng saponins (PNS), the extract of Panax notoginseng, exerts cardioprotective effects in acute myocardial infarction by inducing cardiomyocyte autophagy, inhibiting platelet aggregation, enhancing endothelial cell migration and angiogenesis. PNS and its main constituents Rg1 and Rd also directly inhibit platelet aggregation in healthy subjects and enhance glucose deprivation-induced autophagy in cardiomyocytes. These findings provide insights for drug development from natural products against ischemic heart diseases and heart failure post myocardial infarction.

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