4.6 Article

Panax notoginseng Saponin Protects Against Diabetic Cardiomyopathy Through Lipid Metabolism Modulation

期刊

出版社

WILEY
DOI: 10.1161/JAHA.121.023540

关键词

diabetic cardiomyopathy; lipid metabolism; mitochondria; oxidative stress; PNS

资金

  1. National Natural Science Foundation of China [81773936]
  2. CAMS Innovation Fund for Medical Sciences (CIFMS) [2020-I2 M-2-01]
  3. Key Laboratory Project of CAMS [2018PT35030]
  4. Key R&D projects in Guangdong Province [2020B1111110002]
  5. Major Program of the National Natural Science Foundation of China [81891012]

向作者/读者索取更多资源

This study found that Panax notoginseng saponin (PNS) can attenuate heart dysfunction in diabetic mice by reducing lipotoxicity, modulating oxidative stress, and improving mitochondrial function.
Background People with diabetes are more likely to develop cardiovascular diseases. Lipotoxicity plays a key role in the development of diabetic cardiomyopathy. Panax notoginseng saponin (PNS) has been used to treat diabetes and obesity. However, the role of PNS in diabetic cardiomyopathy remains unclear. Methods and Results Diabetic db/db mice received high-dose (200 mg/kg per day) or medium-dose (100 mg/kg per day) PNS by gavage for 12 weeks until week 36. Lipid accumulation and cardiac function in diabetic mice were detected and possible mechanisms involved were explored. PNS significantly improved body weight, body fat content, serum lipids, adipocytokines, and antioxidative function in db/db mice. Lipid accumulation in adipose tissue, liver, and heart were also alleviated by PNS treatment. Cardiac function and mitochondrial structure were also improved by PNS. H9c2 cells were treated with palmitate acid, and PNS pretreatment reduced lipid accumulation, mitochondrial reactive oxygen species, as well as improved mitochondrial membrane potential and mitochondrial oxygen consumption rate. Levels of proteins and expression of genes related to glucose and lipid metabolism, antioxidative function, and mitochondrial dynamics were also improved by PNS administration. Conclusions PNS attenuated heart dysfunction in diabetic mice by reducing lipotoxicity as well as modulating oxidative stress and improving mitochondrial function.

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