tensorGSEA: Detecting Differential Pathways in Type 2 Diabetes via Tensor-Based Data Reconstruction

Detecting significant signaling pathways in disease progression highlights the dysfunctions and pathogenic mechanisms of complex disease development. Since tensor decomposition has been proven effective for multi-dimensional data representation and reconstruction, differences between original and tensor-processed data are expected to extract crucial information and differential indication. This paper provides a tensor-based gene set enrichment analysis, called tensorGSEA, based on a data reconstruction method to identify relevant significant pathways during disease development. As a proof-of-concept study, we identify the differential pathways of diabetes in rats. Specifically, we first arrange gene expression profiles of each documented pathway as tensors with three dimensions: genes, samples, and periods. Then we compress tensors into core tensors with lower ranks. The pathways with lower reconstruction rates are obtained after reconstructing gene expression profiles in another state via these cores. Thus, differences underlying pathways are extracted by cross-state data reconstruction between controls and diseases. The experiments reveal several critical pathways with diabetes-specific functions which otherwise cannot be identified by alternative methods. Our proposed tensorGSEA is efficient in evaluating pathways by achieving their empirical statistical significance, respectively. The classification experiments demonstrate that the selected pathways can be implemented as biomarkers to identify the diabetic state. The code of tensorGSEA is available at https://github.com/zhxr37/tensorGSEA.

Automated summary

Detecting significant signaling pathways in disease progression is important for understanding complex disease development. This paper introduces a tensor-based gene set enrichment analysis method, called tensorGSEA, that identifies relevant pathways during disease development by reconstructing multi-dimensional gene expression data. The experiments show that tensorGSEA is efficient in identifying critical pathways with diabetes-specific functions.