Healthcare Innovations to Address the Challenges of the COVID-19 Pandemic

Letter Medicine, General & Internal

Characteristics and Outcomes of Hospitalized Patients in South Africa During the COVID-19 Omicron Wave Compared With Previous Waves

Caroline Maslo et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Automated Assessment of COVID-19 Reporting and Data System and Chest CT Severity Scores in Patients Suspected of Having COVID-19 Using Artificial Intelligence

Nikolas Lessmann et al.

Summary: An AI system was developed to analyze chest CT scans of patients with suspected COVID-19, demonstrating high diagnostic performance and good agreement with human observers' findings.

RADIOLOGY (2021)

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Letter Cardiac & Cardiovascular Systems

Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection

Saurabh Rajpal et al.

JAMA CARDIOLOGY (2021)

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Article Medicine, General & Internal

SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19

Peter Chen et al.

Summary: LY-CoV555, a neutralizing antibody, showed promising results in reducing viral load, improving symptoms, and lowering the risk of hospitalization among patients with mild or moderate Covid-19. While one of the doses appeared to accelerate the decline in viral load, others did not show significant effects by day 11.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

Yu Guo et al.

Summary: This study identified potent antibodies from COVID-19 convalescent patients that can bind to SARS-CoV-2 Spike protein, with further engineered modifications to enhance their effectiveness and safety. The engineered antibody showed promising results in clearing the virus in a rhesus monkey model of COVID-19, suggesting its potential as a treatment option against SARS-CoV-2 related diseases.

NATURE COMMUNICATIONS (2021)

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Article Immunology

Can't Work From Home: Pooled Nucleic Acid Testing of Laboratory Workers During the COVID-19 Pandemic

Stephen A. Rawlings et al.

Summary: The use of pooled nucleic acid testing strategy in a research laboratory not only maintained lab activity, but also saved a significant amount of time and money by increasing the safety margin for returning to work.

OPEN FORUM INFECTIOUS DISEASES (2021)

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Article Biochemistry & Molecular Biology

Genetic modification to design a stable yeast-expressed recombinant SARS-CoV-2 receptor binding domain as a COVID-19 vaccine candidate

Wen-Hsiang Chen et al.

Summary: The study successfully demonstrated that genetic modification can lead to a better-controlled and more stable vaccine candidate, which is crucial for the production of biologics or drugs for human use.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2021)

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Article Multidisciplinary Sciences

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Delphine Planas et al.

Summary: The SARS-CoV-2 B.1.617 Delta variant, first identified in India in 2020, has become dominant in some regions and is spreading to many countries. This variant shows resistance to certain monoclonal antibodies and antibodies in convalescent sera, as well as reduced neutralization by some COVID-19 vaccines. Administration of two doses of the vaccine is needed for a neutralizing response against the Delta variant.

NATURE (2021)

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Article Engineering, Biomedical

Face Coverings, Aerosol Dispersion and Mitigation of Virus Transmission Risk

Ignazio Maria Viola et al.

Summary: Face covers can reduce the risk of virus transmission, but the effectiveness varies depending on the type of mask, with some masks potentially presenting leakage hazards.

IEEE OPEN JOURNAL OF ENGINEERING IN MEDICINE AND BIOLOGY (2021)

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Article Psychiatry

Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA

Maxime Taquet et al.

Summary: This study found that survivors of COVID-19 appear to be at increased risk of psychiatric sequelae, and a psychiatric diagnosis might be an independent risk factor for COVID-19. These findings have implications for clinical services, and prospective cohort studies are warranted to further validate the results.

LANCET PSYCHIATRY (2021)

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Editorial Material Cardiac & Cardiovascular Systems

COVID-19 and the cardiovascular system

Ying-Ying Zheng et al.

NATURE REVIEWS CARDIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome

Nicholas S. Hendren et al.

CIRCULATION (2020)

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Article Otorhinolaryngology

Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

Jerome R. Lechien et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2020)

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Review Clinical Neurology

Neurological manifestations and neuro-invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2

K. Vonck et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

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Article Critical Care Medicine

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

Xiaobo Yang et al.

Lancet Respiratory Medicine (2020)

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Letter Medicine, General & Internal

Postmortem Examination of Patients With COVID-19

Tina Schaller et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

COVID-19 on Chest Radiographs: A Multireader Evaluation of an Artificial Intelligence System

Keelin Murphy et al.

RADIOLOGY (2020)

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Article Medicine, General & Internal

Features of 20133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

Annemarie B. Docherty et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Article Cardiac & Cardiovascular Systems

Exercise in the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) era: A Question and Answer session with the experts Endorsed by the section of Sports Cardiology & Exercise of the European Association of Preventive Cardiology (EAPC)

Raghav T. Bhatia et al.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2020)

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Article Clinical Neurology

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

Ling Mao et al.

JAMA NEUROLOGY (2020)

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Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Article Cardiac & Cardiovascular Systems

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

Tao Guo et al.

JAMA CARDIOLOGY (2020)

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Letter Medicine, General & Internal

Neurologic Features in Severe SARS-CoV-2 Infection

Julie Helms et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Letter Medicine, General & Internal

Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young

Thomas J. Oxley et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Public, Environmental & Occupational Health

Out-of-hospital cardiac arrest during the COVID-19 pandemic in Paris, France: a population-based, observational study

Eloi Marijon et al.

LANCET PUBLIC HEALTH (2020)

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Article Clinical Neurology

The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings

Ross W. Paterson et al.

BRAIN (2020)

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Article Cardiac & Cardiovascular Systems

Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19)

Valentina O. Puntmann et al.

JAMA CARDIOLOGY (2020)

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Article Critical Care Medicine

D-dimer as a biomarker for disease severity and mortality in COVID-19 patients: a case control study

Yumeng Yao et al.

JOURNAL OF INTENSIVE CARE (2020)

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Editorial Material Medicine, General & Internal

Rethinking Covid-19 Test Sensitivity - A Strategy for Containment

Michael J. Mina et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Prabhu S. Arunachalam et al.

SCIENCE (2020)

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Editorial Material Multidisciplinary Sciences

COVID-19 can affect the heart

Eric J. Topol

SCIENCE (2020)

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Review Pharmacology & Pharmacy

Middle East Respiratory Syndrome (MERS) and novel coronavirus disease-2019 (COVID-19): From causes to preventions in Saudi Arabia

Mohammad H. Alyami et al.

SAUDI PHARMACEUTICAL JOURNAL (2020)

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Editorial Material Medicine, General & Internal

Two metres or one: what is the evidence for physical distancing in covid-19?

Nicholas R. Jones et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Article Engineering, Biomedical

Ultrasensitive high-resolution profiling of early seroconversion in patients with COVID-19

Maia Norman et al.

NATURE BIOMEDICAL ENGINEERING (2020)

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Article Biochemistry & Molecular Biology

Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2

Alexandra C. Walls et al.

CELL (2020)

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Article Immunology

Yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1) formulated with aluminum hydroxide induces protective immunity and reduces immune enhancement

Wen-Hsiang Chen et al.

VACCINE (2020)

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Article Medicine, General & Internal

Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology

Rossana Bussani et al.

EBIOMEDICINE (2020)

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Review Psychiatry

Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic

Jonathan P. Rogers et al.

LANCET PSYCHIATRY (2020)

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Article Engineering, Biomedical

Can mHealth Technology Help Mitigate the Effects of the COVID-19 Pandemic?

Catherine P. Adans-Dester et al.

IEEE OPEN JOURNAL OF ENGINEERING IN MEDICINE AND BIOLOGY (2020)

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Article Multidisciplinary Sciences

Rapid functionalisation and detection of viruses via a novel Ca2+-mediated virus-DNA interaction

Nicole C. Robb et al.

SCIENTIFIC REPORTS (2019)

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Article Chemistry, Medicinal

Optimization of the Production Process and Characterization of the Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1), a SARS Vaccine Candidate

Wen-Hsiang Chen et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Healthcare Innovations to Address the Challenges of the COVID-19 Pandemic

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