4.7 Review

ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes

期刊

FRONTIERS IN PLANT SCIENCE
卷 12, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fpls.2021.783881

关键词

autophagy; ATG8; ATG8-interacting motif (AIM); ubiquitin-interacting motif (UIM); selective autophagy receptor (SAR)

向作者/读者索取更多资源

Autophagy, an evolutionarily conserved vacuolar process in plants, is activated upon stress and regulated by multiple AuTophaGy-related genes, with the dual role of ATG8 in autophagosome biogenesis and recruitment of SARs. Dozens of AIM or UIM containing SARs have been identified, but knowledge of these motifs remains obscure.
Autophagy is an evolutionarily conserved vacuolar process functioning in the degradation of cellular components for reuse. In plants, autophagy is generally activated upon stress and its regulation is executed by numbers of AuTophaGy-related genes (ATGs), of which the ATG8 plays a dual role in both biogenesis of autophagosomes and recruitment of ATG8-interacting motif (AIM) anchored selective autophagy receptors (SARs). Such motif is either termed as AIM or ubiquitin-interacting motif (UIM), corresponding to the LC3-interacting region (LIR)/AIM docking site (LDS) or the UIM docking site (UDS) of ATG8, respectively. To date, dozens of AIM or UIM containing SARs have been characterized. However, the knowledge of these motifs is still obscured. In this review, we intend to summarize the current understanding of SAR proteins and discuss the conservation and diversification of the AIMs/UIMs, expectantly providing new insights into the evolution of them in various biological processes in plants.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据