期刊
FRONTIERS IN MICROBIOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2022.835040
关键词
CRISPR-Cas13d; CasRx; SVV; antiviral; virus
类别
资金
- National Natural Science Foundation of China [32002249]
- State Key Laboratory of Veterinary Biotechnology of CAAS [SKLVBP201803]
In recent years, Seneca Valley virus (SVV) has emerged as a newly identified pathogen of porcine vesicular disease, spreading quickly and posing a potential threat to the swine industry in multiple countries. Currently, there are no commercial vaccines or drugs available to combat SVV, highlighting the need for strategies to prevent and control SVV infection. A study found that the CRISPR-Cas13d system significantly inhibited SVV replication and demonstrated potent anti-SVV activity, offering a novel alternative strategy to control SVV epidemics in the future.
In recent years, Seneca Valley virus (SVV) as a newly identified pathogen of porcine vesicular disease spread quickly and has posed a potential threat to the swine industry in several countries resulting in economic losses. Considering the evolution of SVV, attention should be given to controlling SVV epidemics. So far there are no commercial vaccines or drugs available to combat SVV. Therefore, development of strategies for preventing and controlling SVV infection should be taken into account. In the current study, we evaluated whether the CRISPR-Cas13d system could be used as a powerful tool against SVV infection. Besides, selected crRNAs showed different capacity against SVV infection. Our study suggests the CRISPR-Cas13d system significantly inhibited SVV replication and exhibited potent anti-SVV activity. This knowledge may provide a novel alternative strategy to control epidemics of SVV in the future.
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