期刊
FRONTIERS IN MICROBIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.737288
关键词
inhibitor; regulation; drug resistance; Gram-negative bacteria; multidrug efflux pumps
类别
Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from bacterial cells, contributing to multidrug resistance. They are abundant in bacteria, and their co-crystal structural analysis reveals drug recognition and export mechanisms, emphasizing the importance of developing inhibitors to combat infectious diseases caused by multidrug-resistant bacteria.
Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug efflux pumps exist in bacteria. Also, the co-crystal structural analysis of multidrug efflux pumps revealed the drug recognition and export mechanisms, and the inhibitory mechanisms of the pumps. A single multidrug efflux pump can export multiple antibiotics; hence, developing efflux pump inhibitors is crucial in overcoming infectious diseases caused by multidrug-resistant bacteria. This review article describes the role of multidrug efflux pumps in MDR, and their physiological functions and inhibitory mechanisms.
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