期刊
FRONTIERS IN MICROBIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.730809
关键词
hypertension; blood pressure; short-chain fatty acids; gut microbiota; mechanism; treatment
类别
资金
- Clinical Research Fund Project of Zhejiang Medical Association [2021ZYC-A46]
- Guiding Scientific and Technological Project of Quzhou [2021007]
This article reviews the potential mechanisms of short-chain fatty acids in regulating blood pressure and their prospects as a target for preventing and treating hypertension.
Hypertension is a significant risk factor for cardiovascular and cerebrovascular diseases, and its development involves multiple mechanisms. Gut microbiota has been reported to be closely linked to hypertension. Short-chain fatty acids (SCFAs)-the metabolites of gut microbiota-participate in hypertension development through various pathways, including specific receptors, immune system, autonomic nervous system, metabolic regulation and gene transcription. This article reviews the possible mechanisms of SCFAs in regulating blood pressure and the prospects of SCFAs as a target to prevent and treat hypertension.
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