期刊
FRONTIERS IN MICROBIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.786042
关键词
SARS-CoV-2; COVID-19; saliva; viral load; virus isolation; real-time reverse transcription PCR; infectivity; quantitative
类别
资金
- Curaden AG, Kriens, Switzerland
- Health, Systemic, Process EA 4129 Research Unit, University of Lyon, France
The fast spread of COVID-19 is related to the highly infectious nature of SARS-CoV-2. This study analyzed the relationship between salivary viral load and demographics and clinical characteristics in 160 adult COVID-19 patients. The study found that SARS-CoV-2 RNA viral load was associated with headache and gastro-intestinal symptoms, suggesting that the oral cavity is an important site for SARS-CoV-2 infection and saliva may be a potential route of transmission.
The fast spread of COVID-19 is related to the highly infectious nature of SARS-CoV-2. The disease is suggested to be transmitted through saliva droplets and nasal discharge. The saliva quantification of SARS-CoV-2 in real-time PCR from asymptomatic or mild COVID-19 adults has not been fully documented. This study analyzed the relationship between salivary viral load on demographics and clinical characteristics including symptoms, co-morbidities in 160 adults diagnosed as COVID-19 positive patients recruited between September and December 2020 in four French centers. Median initial viral load was 4.12 log(10) copies/mL (IQR 2.95-5.16; range 0-10.19 log(10) copies/mL). 68.6% of adults had no viral load detected. A median load reduction of 23% was observed between 0-2 days and 3-5 days, and of 11% between 3-5 days and 6-9 days for the delay from onset of symptoms to saliva sampling. No significant median difference between no-symptoms vs. symptoms patients was observed. Charge was consistently similar for the majority of the clinical symptoms excepted for headache with a median load value of 3.78 log(10) copies/mL [1.95-4.58] (P < 0.003). SARS-CoV-2 RNA viral load was associated with headache and gastro-intestinal symptoms. The study found no statistically significant difference in viral loads between age groups, sex, or presence de co-morbidity. Our data suggest that oral cavity is an important site for SARS-CoV-2 infection and implicate saliva as a potential route of SARS-CoV-2 transmission.
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