期刊
FRONTIERS IN MICROBIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.742984
关键词
non-coding RNAs; influenza A virus; infection; innate immunity; interferons
类别
资金
- National Natural Science Foundation of China [32030110]
- Program for Outstanding Youth Scientific Research of Fujian Agriculture and Forestry University [xjq202018]
- Educational Research Project for Young and Middle-aged Teachers of Fujian Provincial Department of Education [JAT190126]
- Science and Technology Innovation Project of Fujian Agriculture and Forestry University [CXZX2020058A]
Non-coding RNAs play significant roles in cell regulation and response to viral infections, particularly influenza A virus (IAV). They are associated with innate immunity and involvement of interferons and their stimulated genes (ISGs) during IAV infection.
Non-coding RNAs (ncRNAs) are extensively expressed in various cells and tissues, and studies have shown that ncRNAs play significant roles in cell regulation. However, in the past few decades, the knowledge of ncRNAs has been increased dramatically due to their transcriptional ability and multiple regulatory functions. Typically, regulatory ncRNAs include long ncRNAs (lncRNAs), miRNAs, piRNAs, Y RNAs, vault RNAs, and circular RNAs (circRNAs), etc. Previous studies have revealed that various ncRNAs are involved in the host responses to virus infection and play critical roles in the regulation of host-virus interactions. In this review, we discuss the conceptual framework and biological regulations of ncRNAs to elucidate their functions in response to viral infection, especially influenza A virus (IAV) infection. In addition, we summarize the ncRNAs that are associated with innate immunity and involvement of interferons and their stimulated genes (ISGs) during IAV infection.
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