期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2022.809135
关键词
ASFV; extracellular plasma vesicles; swine; function; proteomics profile
资金
- National Key R&D Program of China [:2021YFD1801300]
- National Natural Science Foundation of China [31941002]
- major science and technology project of Gansu Province [20ZD7NA006]
- Fundamental Research Funds of the Chinese Academy of Agricultural Sciences [Y2019YJ07-01]
African swine fever (ASF) has had a significant impact on pig production in China and the world. Research has found that extracellular vesicles play a critical role in the spread of pathogenic microorganisms and can cause protein differences after infection.
African swine fever (ASF) has brought excellent barriers to swine production in China and the world. Studies have shown that extracellular vesicles mediate the RNA and protein spread of pathogenic microorganisms and RNA and proteins. After infection by pathogenic microorganisms causes significant differences in the proteins contained within extracellular vesicles. Based on the above studies, the extracellular vesicles were extracted from ASF virus (ASFV)-infected swine plasma. And qPCR, western blot, and confocal experiment were carried out. The research shows that extracted extracellular vesicles significantly promote the replication of ASFV in susceptible and non-susceptible cells Proteomics analysis of the extracellular vesicle proteins revealed that ASFV infection could cause significant differences in the protein profile. This study demonstrates that extracellular vesicles play a critical role in ASFV replication and transmission and cause significant differences in the protein profile encapsulated in extracellular vesicles.
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