4.7 Review

Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Infectious Diseases

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial

Shengli Xia et al.

Summary: The inactivated SARS-CoV-2 vaccine, BBIBP-CorV, demonstrated safety and immunogenicity in two age groups. Humoral responses against SARS-CoV-2 were induced in all vaccine recipients by day 42. A two-dose immunisation with 4 mu g vaccine on days 0 and 21 or days 0 and 28 achieved higher neutralising antibody titres compared to other dosing schedules.

LANCET INFECTIOUS DISEASES (2021)

Review Immunology

Nanomaterial Delivery Systems for mRNA Vaccines

Michael D. Buschmann et al.

Summary: This review highlights the recent success of mRNA vaccines in SARS-CoV-2 clinical trials, emphasizing the crucial role of lipid nanoparticles in the delivery systems and providing an analysis of the determinants of lipid nanoparticles' performance in mRNA vaccines.

VACCINES (2021)

Article Infectious Diseases

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial

Zhiwei Wu et al.

Summary: The study showed that CoronaVac vaccine is safe and well tolerated in older adults, and is able to induce neutralizing antibody levels. The highest dose of 3 μg of the vaccine can generate neutralizing antibody levels similar to the 6 μg dose, supporting the use of the 3 μg dose CoronaVac in phase 3 trials.

LANCET INFECTIOUS DISEASES (2021)

Article Infectious Diseases

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial

Yanjun Zhang et al.

Summary: This study investigated the safety, tolerability, and immunogenicity of the COVID-19 vaccine candidate CoronaVac, and found that the 3 μg dose showed higher seroconversion rates in the phase 2 trial.

LANCET INFECTIOUS DISEASES (2021)

Review Immunology

Signaling Through Nucleic Acid Sensors and Their Roles in Inflammatory Diseases

Haruna Okude et al.

Summary: Recognition of pathogen-derived nucleic acids by PRRs is crucial for antiviral immune responses, but abnormal recognition of self-nucleic acids by PRRs is associated with autoimmune diseases.

FRONTIERS IN IMMUNOLOGY (2021)

Review Biotechnology & Applied Microbiology

Emerging concepts in the science of vaccine adjuvants

Bali Pulendran et al.

Summary: Adjuvants are vaccine components that enhance the immune response. Recent advances in understanding the molecular mechanisms and systems vaccinology have revitalized the science and development of novel adjuvants for use in vaccines against COVID-19 and future pandemics.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Pharmacology & Pharmacy

Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants

Sachin Bhagchandani et al.

Summary: Imidazoquinoline derivatives function as synthetic agonists of Toll-like receptors 7 and 8, with potential therapeutic utility in antitumor immunomodulation and vaccine adjuvants. However, challenges such as broad expression profiles, poor pharmacokinetic properties, and associated toxicities hinder their successful clinical translation. Strategies to enhance safety and efficacy through bioconjugates and nanoparticle formulations are being explored to address these barriers.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Biotechnology & Applied Microbiology

Targeting Toll-like receptor 3 in dendritic cells for cancer immunotherapy

Misako Matsumoto et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2020)

Review Cell Biology

Molecular mechanisms and cellular functions of cGAS-STING signalling

Karl-Peter Hopfner et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

Mark J. Mulligan et al.

NATURE (2020)

Review Chemistry, Medicinal

Small molecule agonists of toll-like receptors 7 and 8: a patent review 2014-2020

Madeleine E. Kieffer et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2020)

Review Immunology

RIG-I-like receptors: their regulation and roles in RNA sensing

Jan Rehwinkel et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Critical Care Medicine

Dose Optimization of H56:IC31 Vaccine for Tuberculosis-Endemic Populations A Double-Blind, Placebo-controlled, Dose-Selection Trial

Sara Suliman et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Medicine, Research & Experimental

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

Kimberly J. Hassett et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

Review Biochemistry & Molecular Biology

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

Nathan Kelley et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Immunology

Flagellin as a vaccine adjuvant

Baofeng Cui et al.

EXPERT REVIEW OF VACCINES (2018)

Reprint Medicine, General & Internal

A Two-Dose Hepatitis B Vaccine for Adults (Heplisav-B) (Reprinted from The Medical Letter on Drugs and Therapeutics vol 60, pg 17-18, 2018)

Mark Abramowicz et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Biochemistry & Molecular Biology

Vaccine adjuvant ARNAX promotes mucosal IgA production in influenza HA vaccination

Yohei Takeda et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Hematology

Enhancing immunotherapy of STING agonist for lymphoma in preclinical models

Adrienne Sallets et al.

BLOOD ADVANCES (2018)

Article Medicine, Research & Experimental

Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response

Darin K. Edwards et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

Review Immunology

AS03-and MF59-Adjuvanted influenza vaccines in Children

Amanda L. Wilkins et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Immunology

Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21

Iain Welsby et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Biochemistry & Molecular Biology

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants

Robyn Marty-Roix et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

Vijay A. K. Rathinam et al.

Article Dermatology

Natural STING Agonist as an Ideal Adjuvant for Cutaneous Vaccination

Ji Wang et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)

Article Multidisciplinary Sciences

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu et al.

NATURE (2016)

Article Multidisciplinary Sciences

Central Role of CD169+ Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01

Sophie Detienne et al.

SCIENTIFIC REPORTS (2016)

Article Immunology

Harnessing the beneficial heterologous effects of vaccination

Helen S. Goodridge et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

Detection of liposomal cholesterol and monophosphoryl lipid A by QS-21 saponin and Limulus polyphemus amebocyte lysate

Zoltan Beck et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2015)

Review Oncology

MGN1703, an immunomodulator and toll-like receptor 9 (TLR-9) agonist: From bench to bedside

Burghardt Wittig et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2015)

Review Public, Environmental & Occupational Health

Comparative Safety of Vaccine Adjuvants: A Summary of Current Evidence and Future Needs

Nikolai Petrovsky

DRUG SAFETY (2015)

Editorial Material Immunology

Pediatric Vaccine Adjuvants Components of the Modern Vaccinologist's Toolbox

David J. Dowling et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2015)

Article Multidisciplinary Sciences

Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo

Misako Matsumoto et al.

NATURE COMMUNICATIONS (2015)

Review Immunology

Vaccine adjuvant uses of poly-IC and derivatives

Karen Ao Martins et al.

EXPERT REVIEW OF VACCINES (2015)

Article Immunology

Identification of Aim2 as a Sensor for DNA Vaccines

John J. Suschak et al.

JOURNAL OF IMMUNOLOGY (2015)

Article Multidisciplinary Sciences

Delivering HIV Gagp24 to DCIR Induces Strong Antibody Responses In Vivo

Anne-Laure Flamar et al.

PLOS ONE (2015)

Article Cell Biology

Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors

Surya Pandey et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Review Immunology

Vaccine Adjuvants: from 1920 to 2015 and Beyond

Alberta Di Pasquale et al.

VACCINES (2015)

Article Immunology

Flagellin Induces Antibody Responses through a TLR5-and Inflammasome-Independent Pathway

Americo Harry Lopez-Yglesias et al.

JOURNAL OF IMMUNOLOGY (2014)

Article Multidisciplinary Sciences

Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice

Ivana Skrnjug et al.

PLOS ONE (2014)

Article Biotechnology & Applied Microbiology

A nanoliposome delivery system to synergistically trigger TLR4 AND TLR7

Christopher B. Fox et al.

JOURNAL OF NANOBIOTECHNOLOGY (2014)

Article Oncology

STING Ligand c-di-GMP Improves Cancer Vaccination against Metastatic Breast Cancer

Dinesh Chandra et al.

CANCER IMMUNOLOGY RESEARCH (2014)

Article Medicine, Research & Experimental

Genuine Immunomodulation With dSLIM

Kerstin Kapp et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2014)

Review Immunology

Toll-like receptor signaling pathways

Takumi Kawasaki et al.

FRONTIERS IN IMMUNOLOGY (2014)

Review Immunology

The history of MF59 (R) adjuvant: a phoenix that arose from the ashes

Derek T. O'Hagan et al.

EXPERT REVIEW OF VACCINES (2013)

Review Immunology

The use of Toll-like receptor 7/8 agonists as vaccine adjuvants

John P. Vasilakos et al.

EXPERT REVIEW OF VACCINES (2013)

Article Biotechnology & Applied Microbiology

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

Charlotte Pollard et al.

MOLECULAR THERAPY (2013)

Article Multidisciplinary Sciences

The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination

Maria Vono et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Immunology

Vaccine adjuvant formulations: A pharmaceutical perspective

Luis A. Brito et al.

SEMINARS IN IMMUNOLOGY (2013)

Review Biotechnology & Applied Microbiology

A novel, disruptive vaccination technology Self-adjuvanted RNActive® vaccines

Karl-Josef Kallen et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2013)

Review Biotechnology & Applied Microbiology

Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research

Elena Mata et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Review Immunology

Mechanisms of action of adjuvants

Sunita Awate et al.

FRONTIERS IN IMMUNOLOGY (2013)

Article Biochemistry & Molecular Biology

Antigen depot is not required for alum adjuvanticity

Sharon Hutchison et al.

FASEB JOURNAL (2012)

Article Biochemistry & Molecular Biology

A Comparative Study of Stress-mediated Immunological Functions with the Adjuvanticity of Alum

Yufei Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Chemistry, Medicinal

Influence of formulation pH and suspension state on freezing-induced agglomeration of aluminum adjuvants

Maya S. Salnikova et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2012)

Review Immunology

Sensing and reacting to microbes through the inflammasomes

Luigi Franchi et al.

NATURE IMMUNOLOGY (2012)

Article Biochemistry & Molecular Biology

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

Yasuo Tanaka et al.

SCIENCE SIGNALING (2012)

Article Microbiology

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

Jonathan L. Levinsohn et al.

PLOS PATHOGENS (2012)

Article Microbiology

Trained Immunity: A Memory for Innate Host Defense

Mihai G. Netea et al.

CELL HOST & MICROBE (2011)

Review Immunology

Recent clinical experience with vaccines using MPL- and QS-21-containing Adjuvant Systems

Nathalie Garcon et al.

EXPERT REVIEW OF VACCINES (2011)

Review Immunology

Immune Signaling by RIG-I-like Receptors

Yueh-Ming Loo et al.

IMMUNITY (2011)

Article Medicine, Research & Experimental

Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets

Kathrin Kastenmueller et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Review Immunology

Immunological mechanisms of vaccination

Bali Pulendran et al.

NATURE IMMUNOLOGY (2011)

Article Biochemistry & Molecular Biology

Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

Tracy L. Flach et al.

NATURE MEDICINE (2011)

Article Multidisciplinary Sciences

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

Anja Seubert et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59

Ali H. Ellebedy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates

Barbara J. Flynn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Pharmacology & Pharmacy

The pharmacokinetics of Toll-like receptor agonists and the impact on the immune system

Abbi L Engel et al.

Expert Review of Clinical Pharmacology (2011)

Article Immunology

TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin

Matam Vijay-Kumar et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2010)

Article Biochemistry & Molecular Biology

3′,5′-Cyclic diguanylic acid elicits mucosal immunity against bacterial infection

Hongbin Yan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Biotechnology & Applied Microbiology

Characterization of the freeze sensitivity of a hepatitis B vaccine

Dexiang Chen et al.

HUMAN VACCINES (2009)

Review Immunology

The roles of TLRs, RLRs and NLRs in pathogen recognition

Taro Kawai et al.

INTERNATIONAL IMMUNOLOGY (2009)

Review Biochemistry & Molecular Biology

Host Responses from Innate to Adaptive Immunity after Vaccination: Molecular and Cellular Events

Sang-Moo Kang et al.

MOLECULES AND CELLS (2009)

Article Multidisciplinary Sciences

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Hiroki Ishikawa et al.

NATURE (2009)

Review Biochemistry & Molecular Biology

Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant

C. R. Casella et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Editorial Material Immunology

Alum adjuvanticity: Unraveling a century old mystery

Ennio De Gregorio et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2008)

Article Multidisciplinary Sciences

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

Ken J. Ishii et al.

NATURE (2008)

Article Multidisciplinary Sciences

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

Stephanie C. Eisenbarth et al.

NATURE (2008)

Article Multidisciplinary Sciences

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Hiroki Ishikawa et al.

NATURE (2008)

Article Multidisciplinary Sciences

Molecular and cellular signatures of human vaccine adjuvants

F. Mosca et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Biotechnology & Applied Microbiology

Review of hepatitis B surface antigen-1018 ISS adjuvant-containing vaccine safety and efficacy

Mazin Barry et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2007)

Review Biochemistry & Molecular Biology

The dsRNA protein kinase PKR:: Virus and cell control

M. A. Garcia et al.

BIOCHIMIE (2007)

Article Immunology

New hepatitis B vaccine formulated with an improved adjuvant system

Michael Kundi

EXPERT REVIEW OF VACCINES (2007)

Review Biochemistry & Molecular Biology

Pathogen recognition and innate immunity

S Akira et al.

Review Biochemistry & Molecular Biology

RNase L: Its biological roles and regulation

Shu-Ling Liang et al.

IUBMB LIFE (2006)

Article Multidisciplinary Sciences

HIV Gag protein conjugated to a toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates

U Wille-Reece et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Interferon-β induction through Toll-like receptor 3 depends on double-stranded RNA structure

S Okahira et al.

DNA AND CELL BIOLOGY (2005)

Review Microbiology

Vaccines for tuberculosis: Novel concepts and recent progress

TM Doherty et al.

CLINICAL MICROBIOLOGY REVIEWS (2005)

Article Biochemical Research Methods

Separation and quantification of a novel two-component vaccine adjuvant

CE Kritsch et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2005)

Article Multidisciplinary Sciences

Toll-like receptor 3 promotes cross-priming to virus-infected cells

O Schulz et al.

NATURE (2005)

Article Immunology

Toll-like receptors: linking innate and adaptive immunity

C Pasare et al.

MICROBES AND INFECTION (2004)