4.7 Article

HPV16-LINC00393 Integration Alters Local 3D Genome Architecture in Cervical Cancer Cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Circular noncoding RNA circ_0007334 sequestrates miR-577 to derepress KLF12 and accelerate colorectal cancer progression

Liang Bai et al.

Summary: This study reveals that circ_0007334 acts as a tumor suppressor in colorectal cancer (CRC) through the miR-577/KLF12 axis, and exosomal circ_0007334 inhibits tumor growth and angiogenesis in vivo.

ANTI-CANCER DRUGS (2022)

Article Cell Biology

Chromatin Mechanisms Driving Cancer

Berkley Gryder et al.

Summary: The transition of cells from normal to malignant state is primarily driven by oncogenic mutations in conjunction with epigenetic alterations of chromatin. These chromatin alterations can be a result of environmental stressors or genetic mutations that directly affect the structure, levels, or regulatory function of chromatin machinery proteins. These changes disrupt the cell's ability to differentiate along a specific lineage or promote a highly proliferative state dependent on excessive transcriptional output. This article discusses how these genetic alterations exploit the chromatin machinery in the oncogenic process and identify potential vulnerabilities and novel targets for cancer therapy.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2022)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Genetics & Heredity

Kruppel-like factor 12 suppresses bladder cancer growth through transcriptionally inhibition of enolase 2

Cai Tang et al.

Summary: KLF12 was found to be decreased in bladder cancer tissues and cells, and its downregulation was associated with increased proliferation, colony formation, and migration of cancer cells. KLF12 acts as a tumor suppressor by negatively regulating ENO2, which promotes glycolysis in bladder cancer cells. Targeting ENO2 could be a promising treatment strategy for this malignancy.
Article Biotechnology & Applied Microbiology

Integrated analysis of virus and host transcriptomes in cervical cancer in Asian and Western populations

Qiongzi Qiu et al.

Summary: Race may play a role in influencing vulnerability to HPV variants and cervical cancer prevalence. Integrated analysis of virus and host transcriptomes reveals differences in tumor subtypes and immune infiltration between populations, shedding light on racial disparities in HPV-associated cervical cancers.

GENOMICS (2021)

Article Microbiology

Short- and long-range cis interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis

Ian J. Groves et al.

Summary: Research has found that integration of HPV genomes likely occurs through microhomology-mediated repair mechanisms, either directly or via a 'looping' mechanism. Furthermore, chromatin interaction analysis has revealed that interactions between the integrated virus genome and host chromosomes can lead to dysregulation of host genes.

PLOS PATHOGENS (2021)

Article Cell Biology

Structural Variations of the 3D Genome Architecture in Cervical Cancer Development

Muhammad Muzammal Adeel et al.

Summary: The integration of HPV is a major factor in the development of cervical cancer, causing structural variations in the human genome that are associated with changes in the 3D genome structure. Detecting these variations is complex, but techniques such as Hi-C data have helped identify translocations in cervical cancer, providing insights into gene expression and the potential for targeted therapeutics.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Genetics & Heredity

Hi-C Identifies Complex Genomic Rearrangements and TAD-Shuffling in Developmental Diseases

Uira Souto Melo et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2020)

Review Biochemistry & Molecular Biology

Human Virus Transcriptional Regulators

Xing Liu et al.

Article Oncology

Exosomal miR-141 promotes tumor angiogenesis via KLF12 in small cell lung cancer

Shuangshuang Mao et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Article Genetics & Heredity

Alteration of genome folding via contact domain boundary insertion

Di Zhang et al.

NATURE GENETICS (2020)

Article Multidisciplinary Sciences

Integration of molecular profiles in a longitudinal wellness profiling cohort

Abdellah Tebani et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve Oncogenesis

Nicole S. L. Yeo-Teh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Genetics & Heredity

Integrative detection and analysis of structural variation in cancer genomes

Jesse R. Dixon et al.

NATURE GENETICS (2018)

Article Biochemistry & Molecular Biology

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

Zefang Tang et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Microbiology

The role of integration in oncogenic progression of HPV-associated cancers

Alison A. McBride et al.

PLOS PATHOGENS (2017)

Article Biochemistry & Molecular Biology

Tumour-suppression function of KLF12 through regulation of anoikis

N. Godin-Heymann et al.

ONCOGENE (2016)

Article Cell Biology

TAD disruption as oncogenic driver

Anne-Laure Valton et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2016)

Article Biochemical Research Methods

ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization

Guangchuang Yu et al.

BIOINFORMATICS (2015)

Article Multidisciplinary Sciences

Tissue-based map of the human proteome

Mathias Uhlen et al.

SCIENCE (2015)

Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

Article Biochemistry & Molecular Biology

Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability

Keiko Akagi et al.

GENOME RESEARCH (2014)

Article Multidisciplinary Sciences

Topologically associating domains are stable units of replication-timing regulation

Benjamin D. Pope et al.

NATURE (2014)

Article Multidisciplinary Sciences

Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells

Jessica Zuin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

An integrated encyclopedia of DNA elements in the human genome

Ian Dunham et al.

NATURE (2012)

Article Biochemical Research Methods

Fast gapped-read alignment with Bowtie 2

Ben Langmead et al.

NATURE METHODS (2012)

Article Biochemical Research Methods

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

Bo Li et al.

BMC BIOINFORMATICS (2011)

Review Physiology

Mammalian Kruppel-Like Factors in Health and Diseases

Beth B. McConnell et al.

PHYSIOLOGICAL REVIEWS (2010)

Article Multidisciplinary Sciences

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Erez Lieberman-Aiden et al.

SCIENCE (2009)

Article Biotechnology & Applied Microbiology

Model-based Analysis of ChIP-Seq (MACS)

Yong Zhang et al.

GENOME BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)

Article Biochemistry & Molecular Biology

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

R Edgar et al.

NUCLEIC ACIDS RESEARCH (2002)