☆ 4.7 Article

Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Letter Biochemistry & Molecular Biology

Alteration of the respiratory microbiome in COVID-19 patients with different severities

Zhengtu Li et al.

JOURNAL OF GENETICS AND GENOMICS (2022)

添加到收藏夹

Article Immunology

Metatranscriptomic Characterization of Coronavirus Disease 2019 Identified a Host Transcriptional Classifier Associated With Immune Signaling

Haocheng Zhang et al.

Summary: This study analyzed the metatranscriptomic characteristics of COVID-19 and non-COVID-19 pneumonia patients, revealing that COVID-19 patients have a disrupted airway microbiome with reduced alpha diversity, potential pathogenic microbes, and a unique immune-associated host transcriptional signature that could improve diagnosis and indicate disease severity.

CLINICAL INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Allergy

Nasopharyngeal Haemophilus and local immune response during infant respiratory syncytial virus infection

Meghan H. Shilts et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

Yun Kit Yeoh et al.

Summary: This study found that the gut microbiome composition was significantly altered in patients with COVID-19 compared to non-COVID-19 individuals, regardless of medication received. Certain gut commensals known for their immunomodulatory potential were underrepresented in patients and remained low even after disease resolution. Additionally, the altered gut microbiome composition correlated with disease severity and elevated levels of inflammatory cytokines and blood markers.

GUT (2021)

添加到收藏夹

Review Immunology

The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection

Oreste Gallo et al.

Summary: This study critically reviews the latest molecular and cellular findings on the mucosal response to SARS-CoV-2 in the nasal cavity and in NALT, and analyzes its impact on the subsequent course of COVID-19. The possibility of modulating the systemic inflammatory network against the virus starting from the initial phases of the nasal and nasopharyngeal response is explored, with potential clinical and epidemiological implications for mucosal vaccine development.

MUCOSAL IMMUNOLOGY (2021)

添加到收藏夹

Article Environmental Sciences

Investigation of Nasal/Oropharyngeal Microbial Community of COVID-19 Patients by 16S rDNA Sequencing

Martina Rueca et al.

Summary: A study conducted microbial sequencing on 21 patients affected by COVID-19, revealing that patients with severe symptoms showed lower Chao1 and Shannon diversity indices, as well as specific microbial community loss.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

添加到收藏夹

Article Immunology

Nasopharyngeal Microbiome Signature in COVID-19 Positive Patients: Can We Definitively Get a Role to Fusobacterium periodonticum?

Carmela Nardelli et al.

Summary: SARS-CoV-2 infection leads to significant differences in the nasopharyngeal microbiome composition between patients and controls. The reduction of certain bacteria, such as Fusobacterium periodonticum (FP), may affect the pathogenesis of SARS-CoV-2 infection. Further research is needed to elucidate the specific role of FP in COVID-19.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Dysbiosis and structural disruption of the respiratory microbiota in COVID-19 patients with severe and fatal outcomes

Alejandra Hernandez-Teran et al.

Summary: The COVID-19 outbreak has led to over three million deaths worldwide. Research suggests that the respiratory microbiota may be associated with the severity of COVID-19, with potentially opportunistic pathogens and dysbiosis observed in patients, indicating a correlation between respiratory microbiota and clinical outcomes.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Microbiology

Corynebacterium accolens Has Antimicrobial Activity against Staphylococcus aureus and Methicillin-Resistant S. aureus Pathogens Isolated from the Sinonasal Niche of Chronic Rhinosinusitis Patients

Martha Alemayehu Menberu et al.

Summary: Corynebacterium accolens is a dominant species in healthy human nasal microbiota and shows potential antimicrobial activity against Staphylococcus aureus and methicillin-resistant S. aureus. Culture supernatants from C. accolens exhibited significant antibacterial activity and reduced the metabolic activity and biofilm biomass of S. aureus and MRSA clinical isolates, indicating its promise for probiotic therapies to promote sinus health.

PATHOGENS (2021)

添加到收藏夹

Article Biology

Temporal association between human upper respiratory and gut bacterial microbiomes during the course of COVID-19 in adults

Rong Xu et al.

Summary: This study conducted longitudinal analyses of throat and anal microbiomes in 35 COVID-19 patients and 19 healthy controls. Results showed lower bacterial diversity in COVID-19 patients, but observed a synchronous restoration of upper respiratory and gut microbiomes in some mild patients.

COMMUNICATIONS BIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Functional profiling of COVID-19 respiratory tract microbiomes

Niina Haiminen et al.

Summary: During COVID-19 infection, alterations in the lower respiratory tract microbiome function were observed, including decreased potential for lipid metabolism and glycan biosynthesis and metabolism pathways, and increased potential for carbohydrate metabolism pathways. These findings suggest unique functional signatures specific to the lower respiratory tract microbiome during SARS-CoV-2 infection.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Clinical and genomic features of Corynebacterium macginleyi-associated infectious keratitis

Susanna Sagerfors et al.

Summary: Infectious keratitis is a potentially sight threatening ophthalmological emergency often associated with contact lens wear. Corynebacterium macginleyi may be considered a corneal pathogen, and genomic analysis can provide insights into its population structure and disease-causing potential.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Microbiology

Nasopharyngeal Microbial Communities of Patients Infected With SARS-CoV-2 That Developed COVID-19

Maria Paz Ventero et al.

Summary: This study investigated the nasopharynx microbial community of patients with different severity levels of COVID-19, revealing differences in composition of specific OTUs and complexity of co-abundance networks. Taxa with differential abundances could potentially serve as biomarkers for COVID-19 severity, but validation with larger sample sizes is needed.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Biochemical Research Methods

Nasopharyngeal Microbiota in SARS-CoV-2 Positive and Negative Patients

Phillip A. Engen et al.

Summary: The study revealed significant differences in nasopharyngeal microbial community structure between COVID-19-positive and -negative patients, providing preliminary evidence for the relationship between SARS-CoV-2 infection and microbial communities.

BIOLOGICAL PROCEDURES ONLINE (2021)

添加到收藏夹

Article Microbiology

Signatures of COVID-19 Severity and Immune Response in the Respiratory Tract Microbiome

Carter Merenstein et al.

Summary: The study found that patients with COVID-19 have dysbiosis in the respiratory tract microbiome, with significant changes over time, and the diversity of oropharyngeal microbiome at the initial stage is inversely correlated with disease severity. Additionally, microbiome composition is associated with systemic immune parameters, and machine learning analysis indicates early microbiome features can effectively discriminate COVID-19 severity.

MBIO (2021)

添加到收藏夹

Article Microbiology

Oral Microbiome Dysbiosis Is Associated With Symptoms Severity and Local Immune/Inflammatory Response in COVID-19 Patients: A Cross-Sectional Study

Irene Soffritti et al.

Summary: The study revealed that oral dysbiosis in COVID-19 patients is associated with symptom severity and increased local inflammation, while a decreased mucosal immune response was also observed. The characteristics of the HOM may play a significant role in defining individual susceptibility to SARS-CoV-2 infection.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Critical Care Medicine

Ventilator-associated pneumonia in critically ill patients with COVID-19

Mailis Maes et al.

Summary: This study found that COVID-19 patients were more likely to develop VAP, with 3 cases of invasive aspergillosis identified among them and herpesvirade activation being more frequent. The causative organisms of secondary pneumonia observed were similar between COVID-19 and non-COVID-19 patients, suggesting a link to pulmonary dysbiosis caused by COVID-19.

CRITICAL CARE (2021)

添加到收藏夹

Article Immunology

Genomic Diversity of Severe Acute Respiratory Syndrome-Coronavirus 2 in Patients With Coronavirus Disease 2019

Zijie Shen et al.

CLINICAL INFECTIOUS DISEASES (2020)

添加到收藏夹

Editorial Material Medicine, Research & Experimental

Oleoylethanolamide, A Bioactive Lipid Amide, as A Promising Treatment Strategy for Coronavirus/COVID-19

Samad Ghaffari et al.

ARCHIVES OF MEDICAL RESEARCH (2020)

添加到收藏夹

Review Infectious Diseases

Co-infections in people with COVID-19: a systematic review and meta-analysis

Louise Lansbury et al.

JOURNAL OF INFECTION (2020)

添加到收藏夹

Article Biochemical Research Methods

Nasopharyngeal Microbiota Profiling of SARS-CoV-2 Infected Patients

Flavio De Maio et al.

BIOLOGICAL PROCEDURES ONLINE (2020)

添加到收藏夹

Letter Medicine, General & Internal

Swabs Collected by Patients or Health Care Workers for SARS-CoV-2 Testing

Yuan-Po Tu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Editorial Material Otorhinolaryngology

Interim analysis of an open-label randomized controlled trial evaluating nasal irrigations in non-hospitalized patients with coronavirus disease 2019

Kyle S. Kimura et al.

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY (2020)

添加到收藏夹

Article Microbiology

Metagenomic Next-Generation Sequencing of Nasopharyngeal Specimens Collected from Confirmed and Suspect COVID-19 Patients

Heba H. Mostafa et al.

MBIO (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Evaluation of the upper airway microbiome and immune response with nasal epithelial lining fluid absorption and nasal washes

Meghan H. Shilts et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Review Immunology

How COVID-19 induces cytokine storm with high mortality

Shintaro Hojyo et al.

INFLAMMATION AND REGENERATION (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Microbiome-Transcriptome Interactions Related to Severity of Respiratory Syncytial Virus Infection

Abhijeet R. Sonawane et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Microbiology

Haemophilus is overrepresented in the nasopharynx of infants hospitalized with RSV infection and associated with increased viral load and enhanced mucosal CXCL8 responses

Thomas H. A. Ederveen et al.

MICROBIOME (2018)

添加到收藏夹

Article Microbiology

Simple statistical identification and removal of contaminant sequences in marker-gene and metagenomics data

Nicole M. Davis et al.

MICROBIOME (2018)

添加到收藏夹

Review Microbiology

The microbiota of the respiratory tract: gatekeeper to respiratory health

Wing Ho Man et al.

NATURE REVIEWS MICROBIOLOGY (2017)

添加到收藏夹

Article Microbiology

Stress and stability: applying the Anna Karenina principle to animal microbiomes

Jesse R. Zaneveld et al.

NATURE MICROBIOLOGY (2017)

添加到收藏夹

Article Ecology

Minimally Invasive Sampling Method Identifies Differences in Taxonomic Richness of Nasal Microbiomes in Young Infants Associated with Mode of Delivery

Meghan H. Shilts et al.

MICROBIAL ECOLOGY (2016)

添加到收藏夹

Article Critical Care Medicine

Nasopharyngeal Microbiota, Host Transcriptome, and Disease Severity in Children with Respiratory Syncytial Virus Infection

Wouter A. A. de Steenhuijsen Piters et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

添加到收藏夹

Article Biochemical Research Methods

DADA2: High-resolution sample inference from Illumina amplicon data

Benjamin J. Callahan et al.

NATURE METHODS (2016)

添加到收藏夹

Article Microbiology

Corynebacterium accolens Releases Antipneumococcal Free Fatty Acids from Human Nostril and Skin Surface Triacylglycerols

Lindsey Bomar et al.

MBIO (2016)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform

James J. Kozich et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2013)

添加到收藏夹

Article Immunology

Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: Implications for pandemic influenza preparedness

David M. Morens et al.

JOURNAL OF INFECTIOUS DISEASES (2008)

添加到收藏夹

Article Immunology

Enteric salmonellosis disrupts the microbial ecology of the murine gastrointestinal tract

Melissa Barman et al.

INFECTION AND IMMUNITY (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

SILVA:: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB

Elmar Pruesse et al.

NUCLEIC ACIDS RESEARCH (2007)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.