4.8 Letter

Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'

期刊

ELIFE
卷 11, 期 -, 页码 -

出版社

eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.75922

关键词

parasite life cycle; trypanosoma; Tsetse fly; Other

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资金

  1. Deutsche Forschungsgemeinschaft [396187369, EN305, SPP1726, GRK2157]
  2. German-Israeli Foundation for Scientific Research and Development [I-473-416.13/2018]
  3. Bundesministerium fur Bildung und Forschung BMBF NUM Organostrat

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This study discusses two possible interpretations of the trypanosome life cycle and argues for a model that allows for phenotypic plasticity in the slender stage and stochasticity in the trypanosome life cycle.
We thank Keith Matthews and Stephen Larcombe for their thoughtful comment, which follows the good tradition of public scientific discourse (Matthews and Larcombe, 2022). While their remarks have prompted us to take another critical look at our data, we think that they neither alter our conclusions nor offer a practical alternative explanation. In essence, we see two possible interpretations of our experiments: either the trypanosome life cycle can accommodate a more flexible role for the slender stage, or the definition of the stumpy stage needs to be radically changed. While the first interpretation - which we favour - would not falsify any published work, the second one - which Matthews and Larcombe are proposing - would contradict the literature. Hence, we favour a model with an unexpected phenotypic plasticity for the slender stage and a certain degree of stochasticity in the trypanosome life cycle.

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