期刊
ELIFE
卷 11, 期 -, 页码 -出版社
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.72917
关键词
myelin; Schwann cells; class II HDACs; gene compensation; nerve development; nerve regeneration; Mouse; Rat
类别
资金
- Ministerio de Economia y Competitividad [BFU2016-75864R, PID2019-109762RB-I00]
- ISABIAL [UGP18-257, UGP-2019-128]
- Conselleria de Cultura, Educacion y Ciencia, Generalitat Valenciana [PROMETEO 2018/114, ACIF/2 017/169]
- Ministerio de Educacion, Cultura y Deporte [FPU16/00283]
- Wellcome Trust [206634/Z/17/Z]
- Wellcome Trust [206634/Z/17/Z] Funding Source: Wellcome Trust
This study uncovers a finely tuned compensatory mechanism within the class IIa histone deacetylase family, coordinated by distinct transcription factors, that guarantees the ability of Schwann cells to myelinate during development and remyelinate after nerve injury.
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5, and 7 but not Hdac9. Here, we show that a transcription factor regulated genetic compensatory mechanism within this family of proteins, blocks negative regulators of myelination ensuring peripheral nerve developmental myelination and remyelination after injury. Thus, when Hdac4 and 5 are knocked-out from Schwann cells in mice, a JUN-dependent mechanism induces the compensatory overexpression of Hdac7 permitting, although with a delay, the formation of the myelin sheath. When Hdac4, 5, and 7 are simultaneously removed, the myocyte-specific enhancer-factor d (MEF2D) binds to the promoter and induces the de novo expression of Hdac9, and although several melanocytic lineage genes are misexpressed and Remak bundle structure is disrupted, myelination proceeds after a long delay. Thus, our data unveil a finely tuned compensatory mechanism within the class IIa Hdac family, coordinated by distinct transcription factors, that guarantees the ability of Schwann cells to myelinate during development and remyelinate after nerve injury.
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