Science Forum: Is preclinical research in cancer biology reproducible enough?

Article Oncology

Can Oncologists Predict the Efficacy of Treatments in Randomized Trials?

Daniel M. Benjamin et al.

Summary: Individual and aggregated expert opinions were found to be unreliable in predicting outcomes of randomized trials in cancer, highlighting the importance of basing decisions on randomized trials rather than expert opinions.

ONCOLOGIST (2021)

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Article Biotechnology & Applied Microbiology

Improving target assessment in biomedical research: the GOT-IT recommendations

Christoph H. Emmerich et al.

Summary: Academic research plays a crucial role in identifying new drug targets, and this Perspective introduces a framework to assist academic scientists and funders in prioritizing target assessment activities to achieve scientific goals and objectives related to licensing, industry collaboration, and clinical trials.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Biology

Improving preclinical studies through replications

Natascha Ingrid Drude et al.

Summary: The purpose of preclinical research is to guide the development of novel diagnostics or therapeutics, with results from animal models informing decisions on human studies. Despite apparent efficacy demonstrated in preclinical studies, a significant number of clinical trials still fail. Large-scale replication studies are currently investigating factors influencing the robustness of preclinical research.

ELIFE (2021)

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Article Biology

Investigating the replicability of preclinical cancer biology

Timothy M. Errington et al.

Summary: Replicability is an important feature of scientific research, but aspects of contemporary research culture, such as an emphasis on novelty, can make replicability seem less important than it should be. The Reproducibility Project: Cancer Biology aimed to provide evidence about the replicability of preclinical research in cancer biology by repeating selected experiments from high-impact papers. The study found that most of the original effects were positive effects, and in replication experiments, the effect sizes were generally smaller compared to the original experiments.

ELIFE (2021)

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Article Biology

Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

Timothy M. Errington et al.

Summary: Out of the remaining 11 papers, four initiated experimental work but stopped without any outcomes, two resulted in incomplete outcomes due to unexpected challenges, and five had only some experiments completed due to technical or methodological challenges. This provides evidence of the challenges in repeating preclinical cancer biology experiments and the replicability of completed experiments.

ELIFE (2021)

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Article Biology

Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology

Timothy M. Errington et al.

Summary: The study found that replicating preclinical research in cancer biology poses various challenges and barriers, such as lack of key data, insufficient experimental descriptions, and difficulties in obtaining author assistance, limiting the number of successful replications.

ELIFE (2021)

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Review Health Care Sciences & Services

Systematic review and narrative review lead experts to different cancer trial predictions: a randomized trial

Michael Yu et al.

Summary: This study compared the impact of narrative review (NR) and systematic review (SR) on expert assessments of a clinical trial, revealing that experts who read the NR made different predictions and evaluations compared to those who read SR. These differences suggest a potential source of unaddressed bias in ethical review processes.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2021)

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Editorial Material Multidisciplinary Sciences

Against pandemic research exceptionalism

Alex John London et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Publication rates in animal research. Extent and characteristics of published and non-published animal studies followed up at two German university medical centres

Susanne Wieschowski et al.

PLOS ONE (2019)

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Article Biochemistry & Molecular Biology

Rethinking research reproducibility

Ulrich Dirnagl

EMBO JOURNAL (2019)

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Editorial Material Oncology

The paradox of precision medicine

Jonathan Kimmelman et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Article Psychology, Experimental

Do Researchers Anchor Their Beliefs on the Outcome of an Initial Study? Testing the Time-Reversal Heuristic

Anja Franziska Ernst et al.

EXPERIMENTAL PSYCHOLOGY (2018)

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Article Psychology, Biological

Evaluating the replicability of social science experiments in Nature and Science between 2010 and 2015

Colin F. Camerer et al.

NATURE HUMAN BEHAVIOUR (2018)

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Editorial Material Multidisciplinary Sciences

No publication without confirmation

Jeffrey S. Mogil et al.

NATURE (2017)

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Article Medicine, General & Internal

Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13

Courtney Davis et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

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Article Biochemistry & Molecular Biology

Can cancer researchers accurately judge whether preclinical reports will reproduce?

Daniel Benjamin et al.

PLOS BIOLOGY (2017)

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Article Medicine, General & Internal

Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13

Courtney Davis et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

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Review Oncology

Interrogating open issues in cancer precision medicine with patient-derived xenografts

Annette T. Byrne et al.

NATURE REVIEWS CANCER (2017)

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Article Multidisciplinary Sciences

Evaluating replicability of laboratory experiments in economics

Colin F. Camerer et al.

SCIENCE (2016)

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Article Multidisciplinary Sciences

Using prediction markets to estimate the reproducibility of scientific research

Anna Dreber et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Multidisciplinary Sciences

Estimating the reproducibility of psychological science

Alexander A. Aarts et al.

SCIENCE (2015)

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Article Biology

Why clinical translation cannot succeed without failure

Alex John London et al.

ELIFE (2015)

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Article Biology

A meta-analysis of threats to valid clinical inference in preclinical research of sunitinib

Valerie C. Henderson et al.

ELIFE (2015)

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Article Biotechnology & Applied Microbiology

Clinical development success rates for investigational drugs

Michael Hay et al.

NATURE BIOTECHNOLOGY (2014)

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Article Biology

An open investigation of the reproducibility of cancer biology research

Timothy M. Errington et al.

ELIFE (2014)

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Article Multidisciplinary Sciences

An investigation of the false discovery rate and the misinterpretation of p-values

David Colquhoun

ROYAL SOCIETY OPEN SCIENCE (2014)

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Article Oncology

Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted?

T. C. Hirst et al.

BRITISH JOURNAL OF CANCER (2013)

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Review Neurosciences

Power failure: why small sample size undermines the reliability of neuroscience

Katherine S. Button et al.

NATURE REVIEWS NEUROSCIENCE (2013)

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Article Multidisciplinary Sciences

A Survey on Data Reproducibility in Cancer Research Provides Insights into Our Limited Ability to Translate Findings from the Laboratory to the Clinic

Aaron Mobley et al.

PLOS ONE (2013)

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Editorial Material Multidisciplinary Sciences

Raise standards for preclinical cancer research

C. Glenn Begley et al.

NATURE (2012)

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Letter Biotechnology & Applied Microbiology

Should preclinical studies be registered?

Jonathan Kimmelman et al.

NATURE BIOTECHNOLOGY (2012)

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Letter Biotechnology & Applied Microbiology

Believe it or not: how much can we rely on published data on potential drug targets?

Florian Prinz et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

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Article Psychology, Multidisciplinary

False-Positive Psychology: Undisclosed Flexibility in Data Collection and Analysis Allows Presenting Anything as Significant

Joseph P. Simmons et al.

PSYCHOLOGICAL SCIENCE (2011)

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Article Biochemistry & Molecular Biology

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

Emily S. Sena et al.

PLOS BIOLOGY (2010)

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Science Forum: Is preclinical research in cancer biology reproducible enough?

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