4.8 Article

Population receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex

期刊

ELIFE
卷 10, 期 -, 页码 -

出版社

eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.67304

关键词

population receptive field; vision; nonhuman primate; neuroimaging; neurophysiology; Rhesus macaque

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资金

  1. Nederlandse Organisatie voor Wetenschappelijk Onderzoek [VENI 451.13.023, STW-Perspectief P15-42]
  2. FP7 Ideas: European Research Council [ERC 339490]
  3. Human Brain Project [720270, 785907]
  4. Nederlandse Organisatie voor Wetenschappelijk Onderzoek Crossover Program [17619]

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The research indicates that fMRI-based pRF maps reliably reflect neuronal receptive field properties in the primate brain, especially in areas V1 and V4. In addition, whole-brain fMRI measurements reveal retinotopic tuning in many other areas, as well as a retinotopically specific deactivation of default mode network nodes.
Population receptive field (pRF) modeling is a popular fMRI method to map the retinotopic organization of the human brain. While fMRI-based pRF maps are qualitatively similar to invasively recorded single-cell receptive fields in animals, it remains unclear what neuronal signal they represent. We addressed this question in awake nonhuman primates comparing whole-brain fMRI and large-scale neurophysiological recordings in areas V1 and V4 of the visual cortex. We examined the fits of several pRF models based on the fMRI blood-oxygen-level-dependent (BOLD) signal, multi-unit spiking activity (MUA), and local field potential (LFP) power in different frequency bands. We found that pRFs derived from BOLD-fMRI were most similar to MUA-pRFs in V1 and V4, while pRFs based on LFP gamma power also gave a good approximation. fMRI-based pRFs thus reliably reflect neuronal receptive field properties in the primate brain. In addition to our results in V1 and V4, the whole-brain fMRI measurements revealed retinotopic tuning in many other cortical and subcortical areas with a consistent increase in pRF size with increasing eccentricity, as well as a retinotopically specific deactivation of default mode network nodes similar to previous observations in humans.

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