期刊
BIOMED RESEARCH INTERNATIONAL
卷 2022, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2022/1590815
关键词
-
资金
- Natural Science Foundation of Liaoning Province, China [2019-ZD-0772]
- National Natural Science Foundation of China [81471809, 81971639]
LIFR-AS1 is a lncRNA transcribed in an antisense manner from the LIFR gene on human chromosome, and it plays a role in tumor growth, migration, invasion, apoptosis, and drug resistance through various mechanisms. It has the potential to serve as a biomarker and therapeutic target for different types of human cancers.
Emerging evidence has indicated that aberrantly expressed long noncoding RNAs (lncRNAs) play a vital role in various biological processes associated with tumorigenesis. Leukemia inhibitory factor receptor antisense RNA1 (LIFR-AS1) is a recently identified lncRNA transcribed in an antisense manner from the LIFR gene located on human chromosome 5p13.1. LIFR-AS1 regulates tumor proliferation, migration, invasion, apoptosis, and drug resistance through different mechanisms. Its expression level is related to the clinicopathological characteristics of tumors and plays a key role in tumor occurrence and development. In this review, we summarize the role of LIFR-AS1 in the development and progression of different cancers and highlight the potential for LIFR-AS1 to serve as a biomarker and therapeutic target for a variety of human cancers.
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