Noncoding RNA Roles in Pharmacogenomic Responses to Aspirin: New Molecular Mechanisms for an Old Drug

Aspirin, as one of the most frequently prescribed drugs, can have therapeutic effects on different conditions such as cardiovascular and metabolic disorders and malignancies. The effects of this common cardiovascular drug are exerted through different molecular and cellular pathways. Altered noncoding RNA (ncRNA) expression profiles during aspirin treatments indicate a close relationship between these regulatory molecules and aspirin effects through regulating gene expressions. A better understanding of the molecular networks contributing to aspirin efficacy would help optimize efficient therapies for this very popular drug. This review is aimed at discussing and highlighting the identified interactions between aspirin and ncRNAs and their targeting pathways and better understanding pharmacogenetic responses to aspirin.

Automated summary

Aspirin, a commonly prescribed drug, has therapeutic effects on cardiovascular and metabolic disorders as well as malignancies through various molecular pathways. Changes in noncoding RNA expression profiles during aspirin treatments suggest a close relationship between these regulatory molecules and aspirin effects on gene expressions. Understanding the molecular networks involved in aspirin efficacy could optimize therapies for this popular drug.