4.5 Article

An oral pH-activated nano-bomb carrier combined with berberine by regulating gene silencing and gut microbiota for site-specific treatment of ulcerative colitis

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Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites

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Summary: The study showed that berberine can effectively improve the pathological phenotype, gut barrier disruption, and colon inflammation in rats with DSS-induced colitis. Furthermore, berberine can alleviate gut dysbiosis in rats and improve gut barrier function through the regulation of microbial metabolites to activate AhR.

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