期刊
BIOMATERIALS SCIENCE
卷 10, 期 4, 页码 874-891出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1bm01589c
关键词
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资金
- UK Engineering and Physical Sciences Research Council [EP/L014823/1, EP/R513258/1, EP/P001076/1]
- National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC)
- EPSRC [EP/P001076/1] Funding Source: UKRI
Back pain can affect health and mobility, and nucleus augmentation aims to restore the intervertebral disc to its healthy state through minimally invasive methods. Injectable hydrogels are commonly used materials for nucleus augmentation, and the mechanical properties and biological compatibility of these materials are important factors to consider in their development.
Back pain affects a person's health and mobility as well as being associated with large health and social costs. Lower back pain is frequently caused by degeneration of the intervertebral disc. Current operative and non-operative treatments are often ineffective and expensive. Nucleus augmentation is designed to be a minimally invasive method of restoring the disc to its native healthy state by restoring the disc height, and mechanical and/or biological properties. The majority of the candidate materials for nucleus augmentation are injectable hydrogels. In this review, we examine the materials that are currently under investigation for nucleus augmentation, and compare their ability to meet the design requirements for this application. Specifically, the delivery of the material into the disc, the mechanical properties of the material and the biological compatibility are examined. Recommendations for future testing are also made.
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