Rh(III)-Catalyzed C-H Activation/Annulation of N-Methyl Arylhydrazines with Iodonium Ylides toward Ring-fused Cinnolines

The first Rh(III)-catalyzed annulation of N-methyl arylhydrazines with iodonium ylides was developed. This transformation undergoes cascade C-H activation/annulation, dehydration and demethylative aromatization under very simple reaction conditions, providing a series of oxycycloalkyl-fused cinnolines in good yields.

Automated summary

A new Rh(III)-catalyzed annulation of N-methyl arylhydrazines with iodonium ylides has been developed, providing a series of oxycycloalkyl-fused cinnolines in good yields under very simple reaction conditions.