期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 11, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202200058
关键词
C-D activation; deuteration; palladium carbene; migratory insertion; 1; 4-palladium shift
资金
- NSFC [21871259, 21901244, 22171077]
- China Hunan Provincial Science & Technology Department [2021JJ10005]
- Science and Technology Planning Project of Hunan Province [2018TP1017]
- Hunan Normal University
Deuterated compounds are important in pharmaceutical chemistry and the selective incorporation of deuterium atoms onto pharmacophore-containing compounds is of great interest. In this study, a concise method for constructing deuterated dibenzo-fused epsilon-lactones and epsilon-lactams through Pd-catalyzed carbene bridging C-D bond activation strategy was described. Deuterated ortho-bromobenzaldehydes were readily available reactants and deuterium atoms were selectively incorporated at the dibenylic position with high deuterated ratio.
Since deuterated compounds have significant applications in pharmaceutical chemistry, selective incorporation of deuterium atoms onto a pharmacophore containing compounds has attracted great attention. Herein, we describe a concise method for construction of deuterated dibenzo-fused epsilon-lactones and epsilon-lactams via Pd-catalyzed carbene bridging C-D bond activation strategy. Readily available deuterated ortho-bromobenzaldehydes were employed as reactants, and deuterium atom was selectively incorporated at the dibenylic position with high deuterated ratio.
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