期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 10, 期 12, 页码 3308-3320出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202100476
关键词
Iridium; C-H activation; [3+2] annulation; Tetrasubstituted alkene; pyrrolo[1,2-a]indole
资金
- Zhejiang Provincial Natural Science Foundation of China [LQ19B020003, LY21B020003]
- Science and Technology Program of Sichuan Province [2018JY0345]
- National Natural Science Foundation of China [21602022]
- Chengdu Talents Program
- 1000 Talents Program of Sichuan Province
- Chenghua District Talents Program
- Jinhua Branch of Sichuan Industrial Institute of Antibiotics [1003, SIIAJH-202002, SIIAJH-202006]
- Jinhua Science and Technology Bureau [2021-3-150]
- Chengdu University [2081915037]
- Shanghai Pujiang Program [21PJ1415800]
This novel method demonstrates excellent regio- and stereoselectivity, good substrate scope, and mild redox-neutral conditions, making it a versatile and efficient strategy for synthesizing tetrasubstituted alkenes and pyrrolo[1,2-a]indole derivatives.
We have achieved an Ir(III)-catalyzed temperature-controlled divergent synthesis of tetrasubstituted alkenes and pyrrolo[1,2-a]indole derivatives through C-H alkenylation/DG migration and [3+2] annulation, respectively. This method has various advantageous features: a) excellent regio- and stereoselectivity and good functional group tolerance, b) broad substrate scope and moderate to excellent yields, c) mild redox-neutral reaction conditions and operational simplicity.
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