H2O2-Promoted Alkoxyalkylation of Terminal Alkynes Employing Two Strategies with Transition-Metal-Free Conditions

H2O2-promoted alkoxyalkylation of terminal alkynes by employing two strategies were developed, this is the first example of the direct C(sp(3))-H functionalization of ethers to prepare 2-vinyl heterocycles by using H2O2 as the radical initiator and oxidant. Particularly, this transformation could be conducted without expensive photocatalysts or transition metal catalysts under mild conditions.

Automated summary

Two strategies were developed for the H2O2-promoted alkoxyalkylation of terminal alkynes, allowing for the direct functionalization of ethers to prepare 2-vinyl heterocycles using H2O2 as a radical initiator and oxidant. This transformation can be conducted under mild conditions without the need for expensive photocatalysts or transition metal catalysts.