期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 12, 期 1, 页码 120-132出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.12852
关键词
DAMPs; Immunogenic apoptosis; Antitumor vaccination; Hypericin; CD47
资金
- National Natural Science Foundation of China [81502540]
- Fundamental Research Fund for the Central Universities of China [222201514333]
- Shanghai Committee of Science and Technology [13140902300, 11DZ2260600]
- Nano Science and Technology Special Funding of Shanghai Committee of Science and Technology [11nm0503700]
- Fundamental Research Funds for the Central Universities
Photodynamic therapy (PDT), a regulatory approved cancer treatment, is reported to be capable of causing immunogenic apoptosis. The current data reveal PDT can cause the dysregulation of eat me and don't eat me signal by generating reactive oxygen species (ROS) -mediated endoplasmic reticulum (ER) stress. This dysregulation probably contribute to the increased uptake of PDT-killed Lewis lung carcinoma (LLC) cells by homologous dendritic cells (DCs), accompanied by phenotypic maturation (CD80(high), CD86(high), and CD40(high)) and functional stimulation (NOhigh, IL-10(absent)) of dendritic cells as well as subsequent T-cell responses. Morevover, C57BL/6 mice vaccinated with dendritic cells (DCs) pulsed with PDT-treated LLCs (PDT-DCs) or PDT-treated LLCs alone (PDT-LLCs) exhibited potent immunity against LLC tumors. In the current study, the PDT-induced immune response was characterized as a process related with the dysregulation of eat me signal and don't eat me signal, revealing the possibility for developing PDT into an antitumor vaccination strategy for personalized cancer immunotherapy.
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