期刊
TOXINS
卷 13, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/toxins13110814
关键词
Bothrops atrox; individual variability; venom heterogeneity
资金
- Coordenacao de Aperfeicoamento de Pessoal nivel superior [CAPES 063/2010-Toxinology-AUXPE 1209/2011]
- Fundacao de Amparo a Pesquisa de Sao Paulo [FAPESP 2016/50127-5, 2014/13124-2, 2017/15170-0]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [303958/2018-9]
- Fundacao de Amparo a Pesquisa do Estado do Amazonas-FAPEAM (PRO-ESTADO)
The study found variations in venom composition among individual B. atrox snakes from different habitats, resulting in functional and toxicological uniqueness, especially among snakes from the floodplain area.
Differences in snake venom composition occur across all taxonomic levels and it has been argued that this variation represents an adaptation that has evolved to facilitate the capture and digestion of prey and evasion of predators. Bothrops atrox is a terrestrial pitviper that is distributed across the Amazon region, where it occupies different habitats. Using statistical analyses and functional assays that incorporate individual variation, we analyzed the individual venom variability in B. atrox snakes from four different habitats (forest, pasture, degraded area, and floodplain) in and around the Amazon River in Brazil. We observed venom differentiation between spatially distinct B. atrox individuals from the different habitats, with venom variation due to both common (high abundance) and rare (low abundance) proteins. Moreover, differences in the composition of the venoms resulted in individual variability in functionality and heterogeneity in the lethality to mammals and birds, particularly among the floodplain snakes. Taken together, the data obtained from individual venoms of B. atrox snakes, captured in different habitats from the Brazilian Amazon, support the hypothesis that the differential distribution of protein isoforms results in functional distinctiveness and the ability of snakes with different venoms to have variable toxic effects on different prey.
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