期刊
TOXINS
卷 13, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/toxins13110790
关键词
mycotoxins; zearalenone; adipokines; metabolism; estrogen
资金
- ANR [ANR-17-Carn012]
- Austrian Research Promotion Agency (FFG) [866384]
This study elucidated the role of Zearalenone (ZEN) as a metabolic disruptor in pigs by investigating changes in energy balance and adipokines levels in response to different treatment diets. Results showed that ZEN impacts lipid and glucose metabolism, with effects varying based on dose and exposure time, leading to alterations in adipokine concentrations.
Zearalenone (ZEN) is a mycotoxin classified as an endocrine disruptor. Many endocrine disruptors are also metabolic disruptors able to modulate energy balance and inflammatory processes in a process often involving a family of protein hormones known as adipokines. The aim of our study was to elucidate the role of ZEN as metabolic disruptor in pigs by investigating the changes in energy balance and adipokines levels in response to different treatment diets. To this end, weaned piglets (n = 10/group) were exposed to either basal feed or feed contaminated with 680 and 1620 mu g/kg ZEN for 28 days. Serum samples collected at days 7 and 21 were subjected to biochemistry analysis, followed by determination of adipokine levels using a combined approach of protein array and ELISA. Results indicate that ZEN has an impact on lipid and glucose metabolism that was different depending on the dose and time of exposure. In agreement with these changes, ZEN altered circulating adipokines concentrations, inducing significant changes in adiponectin, resistin, and fetuin B. Our results suggest that ZEN may function as a natural metabolism-disrupting chemical.
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