期刊
POLYMERS
卷 13, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/polym13193282
关键词
selective laser sintering; di-carboxylic acids; plasticizers; solid oral forms; printability; heating temperature
资金
- Algerian Ministry of High Education and Scientific Research
This study investigates the plasticizing effect of di-carboxylic acids on reducing the optimal heating temperature (OHT) of polymer powder during SLS. Succinic acid was found to be the most efficient plasticizer, while only the acid form of ibuprofen demonstrated a plasticizing effect. DSC and FTIR analyses confirmed the decrease in glass transition temperature and the presence of interactions, respectively, without affecting the properties of the sintered SOFs or degrading the API.
In selective laser sintering (SLS), the heating temperature is a critical parameter for printability but can also be deleterious for the stability of active ingredients. This work aims to explore the plasticizing effect of di-carboxylic acids on reducing the optimal heating temperature (OHT) of polymer powder during SLS. First, mixtures of copovidone and di-carboxylic acids (succinic, fumaric, maleic, malic and tartaric acids) as well as formulations with two forms of ibuprofen (acid and sodium salt) were prepared to sinter solid oral forms (SOFs), and their respective OHT was determined. Plasticization was further studied by differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR). Following this, the printed SOFs were characterized (solid state, weight, hardness, disintegration time, drug content and release). It was found that all acids (except tartaric acid) reduced the OHT, with succinic acid being the most efficient. In the case of ibuprofen, only the acid form demonstrated a plasticizing effect. DSC and FTIR corroborated these observations showing a decrease in the glass transition temperature and the presence of interactions, respectively. Furthermore, the properties of the sintered SOFs were not affected by plasticization and the API was not degraded in all formulations. In conclusion, this study is a proof-of-concept that processability in SLS can improve with the use of di-carboxylic acids.
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