期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 85, 期 -, 页码 294-301出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2015.12.089
关键词
Lycium barbarum polysaccharides liposome; Immunological activity; Vaccine adjuvant; Immune responses
资金
- National Natural Science Foundation of China [31372472]
- Special Fund for Agro-scientific Research in the Public Interest [201303046, 201403051]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
In previous researches, the results showed that Lycium barbarum polysaccharides (LBP) encapsulated with liposome could enhance the immune activity of LBP. Therefore, the present study was designed to investigate the effects of LBPL on spleen lymphocytes and macrophages of mice in vitro and evaluate the immunological adjuvant activity of PCV2 vaccine in vivo. The results showed that LBPL could significantly promote splenocyte proliferation synergistically with PHA or LPS, increase the ratio of CD4(+) to CD8(+) T cells and promote the cytokine secretion of macrophages; enhance PCV2-specific IgG antibody responses, promote Th1 cytokines (IFN-gamma and TNF-alpha) and Th2 cytokine (IL-4) secretion. The histomorphological observation of spleen demonstrated that LBPL as a vaccine adjuvant also has good improvement and stimulating effect on the immune organ. (C) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据