Osteoconductive Effect of a Nanocomposite Membrane Treated with UV Radiation

Modulation of the bio-regenerative characteristics of materials is an indispensable requirement in tissue engineering. Particularly, in bone tissue engineering, the promotion of the osteoconductive phenomenon determines the elemental property of a material be used therapeutically. In addition to the chemical qualities of the constituent materials, the three-dimensional surface structure plays a fundamental role that various methods are expected to modulate in a number of ways, one most promising of which is the use of different types of radiation. In the present manuscript, we demonstrate in a calvarial defect model, that treatment with ultraviolet irradiation allows modification of the osteoconductive characteristics in a biomaterial formed by gelatin and chitosan, together with the inclusion of hydroxyapatite and titanium oxide nanoparticles.

Automated summary

Modulating the bio-regenerative characteristics of materials is crucial in tissue engineering, especially in bone tissue engineering where the promotion of osteoconduction determines the therapeutic properties of the material. In addition to chemical qualities, the three-dimensional surface structure plays a fundamental role and can be modulated through various methods, one of which is the use of different types of radiation.