Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer

Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 mu M. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials.

Automated summary

Second-generation type III-B rotaxane dendrons with succinimide and acetylene functional groups were successfully synthesized and characterized. A cell viability study showed low cytotoxicity of the dendrons, indicating potential for development into bio-compatible polymeric materials.