期刊
PLOS GENETICS
卷 17, 期 10, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1009834
关键词
-
资金
- Temasek Life Sciences Laboratory
- Singapore Millennium Foundation
- China Postdoctoral Science Foundation [2020M670063, 2020T130030]
- National Natural Science Foundation of China [31972893, 92054109, 82001200]
- Municipal Natural Science Foundation of Beijing [KZ201910028040]
In this study, dRTEL1 was identified as a novel regulator of male germline stem cells (GSCs), affecting a set of candidate genes required for GSC maintenance and preventing DNA damage-induced checkpoint activation. Additionally, dRTEL1 functions to sustain Stat92E protein levels, providing insight into its role in GSC maintenance.
Stem cells have the potential to maintain undifferentiated state and differentiate into specialized cell types. Despite numerous progress has been achieved in understanding stem cell self-renewal and differentiation, many fundamental questions remain unanswered. In this study, we identify dRTEL1, the Drosophila homolog of Regulator of Telomere Elongation Helicase 1, as a novel regulator of male germline stem cells (GSCs). Our genome-wide transcriptome analysis and ChIP-Seq results suggest that dRTEL1 affects a set of candidate genes required for GSC maintenance, likely independent of its role in DNA repair. Furthermore, dRTEL1 prevents DNA damage-induced checkpoint activation in GSCs. Finally, dRTEL1 functions to sustain Stat92E protein levels, the key player in GSC maintenance. Together, our findings reveal an intrinsic role of the DNA helicase dRTEL1 in maintaining male GSC and provide insight into the function of dRTEL1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据