期刊
PEDIATRIC OBESITY
卷 17, 期 3, 页码 -出版社
WILEY
DOI: 10.1111/ijpo.12859
关键词
adiposity; body composition; infants; metabolomics; skinfolds
类别
资金
- EU Commission [696295]
- Innovation Fund Denmark [4203-00005B]
- Netherlands Organisation for Health Research and Development (ZonMW) [529051013]
- Biotechnology and Biological Sciences Research Council [BB/P028195/1]
- Danone Nutricia Research, The Netherlands
- NIHR Cambridge Biomedical Research Centre [146281]
- Medical Research Council [MC_UU_00006/2]
- BBSRC [BB/P028195/1] Funding Source: UKRI
The study shows that plasma metabolite profile at 3 months can predict body composition at 2 years, especially the ratio of truncal to peripheral fat skinfold. The predictive value is higher in boys, and there is an association with visceral fat at 2 years of age.
Background and Objectives Early life is a critical window for adiposity programming. Metabolic-profile in early life may reflect this programming and correlate with later life adiposity. We investigated if metabolic-profile at 3 months of age is predictive for body composition at 2 years and if there are differences between boys and girls and between infant feeding types. Methods In 318 healthy term-born infants, we determined body composition with skinfold measurements and abdominal ultrasound at 3 months and 2 years of age. High-throughput-metabolic-profiling was performed on 3-month-blood-samples. Using random-forest-machine-learning-models, we studied if the metabolic-profile at 3 months can predict body composition outcomes at 2 years of age. Results Plasma metabolite-profile at 3 months was found to predict body composition at 2 years, based on truncal: peripheral-fat-skinfold-ratio (T:P-ratio), with a predictive value of 75.8%, sensitivity of 100% and specificity of 50%. Predictive value was higher in boys (Q(2) = 0.322) than girls (Q(2) = 0.117). Of the 15 metabolite variables most strongly associated with T:P-ratio, 11 were also associated with visceral fat at 2 years of age. Conclusion Several plasma metabolites (LysoPC(22:2), dimethylarginine and others) at 3 months associate with body composition outcome at 2 years. These results highlight the importance of the first months of life for adiposity programming.
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