期刊
OPEN BIOLOGY
卷 11, 期 12, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.210268
关键词
platelet-derived growth factor C; development; embryogenesis; organogenesis; stem cell; pluripotency
资金
- National Natural Science Foundation of China [82070983, 81870679]
- Program of Guangzhou Scientific Research Plan [202102010179]
- Natural Science Foundation of Guangdong Province [2019A1515010229, 2021A1515010684]
- Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science [2020B1212060033]
- Guangzhou basic and applied research program [202102020146]
- Fundamental Research Funds for the Central Universities [19ykpy151]
PDGF-C is a relatively new member of the PDGF family, expressed in most organs and cell types, and has demonstrated critical roles in various biological, physiological and pathological processes over the past 20 years.
Platelet-derived growth factor C (PDGF-C) is a relatively new member of the PDGF family, discovered nearly 20 years after the finding of platelet-derived growth factor A (PDGF-A) and platelet-derived growth factor B (PDGF-B). PDGF-C is generally expressed in most organs and cell types. Studies from the past 20 years have demonstrated critical roles of PDGF-C in numerous biological, physiological and pathological processes, such as development, angiogenesis, tumour growth, tissue remodelling, wound healing, atherosclerosis, fibrosis, stem/progenitor cell regulation and metabolism. Understanding PDGF-C expression and activities thus will be of great importance to various research disciplines. In this review, however, we mainly discuss the expression and functions of PDGF-C and its receptors in development and stem cells.
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