期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 84, 期 -, 页码 418-427出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2015.12.047
关键词
Chitosan (CS); Quaternary ammonium salt (QAS-CS); Antibacterial; Water solubility; Cytotoxicity
资金
- National Natural Science Foundation of China [21402010]
- Foundation of Shandong province [ZR2013BM022, ZR2014BL008, 2014CGZH1316, 2015GGX102013]
- Foundation of Yantai [2013ZH095]
- Foundation of Binzhou Medical University [BY2012DKCX113]
Five water-soluble O-quaternary ammonium salt-chitosans (QAS-CS) bearing N-methyl-N-R-N, N-bis(2-hydroxyethyl) ammonium bromides (R=-benzyl (chloride, BNQAS-CS),-dodecyl (C12QAS-CS), -tetradecyl (C14QAS-CS),-hexadecyl (C16QAS-CS),-octadecyl (C18QAS-CS)) were prepared, respectively. They were characterized by FTIR, H-1 NMR and elemental analysis. Through chemical modification of O-quaternized chitosans, the water solubility of all QAS-CS was improved distinctly. Their antibacterial properties indicate good antibacterial abilities against gram-positive bacteria and bad against gram negative bacteria, therein, C12QAS-CS and C14QAS-CS are the best. More importantly, their cytotoxicity was markedly lower than the corresponding QAS monomers by evaluating for AT2 cell line using CCK-8 assay. The strategy provides a facile way to design and develop new types of antibacterial chitosan materials with better water solubility, better antimicrobial ability and lower cytotoxicity for primary additive agent of self-owned intellectual band-aids. (C) 2015 Elsevier B.V. All rights reserved.
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