期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 92, 期 -, 页码 645-653出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2016.07.029
关键词
Biocompatible scaffolds; Tissue regeneration; Interconnected matrix
资金
- Brazilian National Council for Scientific and Technological Development (CNPq)
- TWAS, the academy of sciences for the developing world [190232/2014-5 CNPq/TWAS-FR: 3240279900]
Biologically active scaffolds used in tissue engineering and regenerative medicine have been generating promising results in skin replacement. The present study aims to test the hypothesis that the incorporation of Aloe vera and snail mucus into scaffolds based on gelatin and chitosan could improve their structure, composition and biodegradability, with a potential effect on bioactivity. Homogeneous pore diameter as well as pore walls in the composite scaffold could be seen in the SEM image. The pores in the scaffolds were interconnected and their sizes ranged from 93 to 296 mu m. The addition of Aloe vera and snail mucus enlarged the mean pore size with increased porosity and caused changes in the pore architecture. The FTIR analysis has shown good affinity and interaction between the matrix and the Aloe, which may decrease water-binding sites, so this fact hindered the water absorption capacity of the material. The mechanical properties could explain the highest swelling capacity of the snail scaffold, because the high percentage of elongation could facilitate the entry of liquid in it, generating a matrix with plenty of fluid retention. The real innovation in the present work could be the use of these substances (Aloe and snail mucus) for tissue engineering. (C) 2016 Elsevier B.V. All rights reserved.
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