期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 79, 期 -, 页码 360-369出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2016.09.002
关键词
Curcumin; Exosomes; Neurons; Stroke
资金
- National Institute of Health (NIH), USA [HL-074185, HL-107640]
- American Heart Association, USA [15POST23110021]
We tested whether the combined nano-formulation, prepared with curcumin (anti-inflammatory and neuroprotective molecule) and embryonic stem cell exosomes (MESC-exo(cur)), restored neurovascular loss following an ischemia reperfusion (IR) injury in mice. IR-injury was created in 8-10 weeks old mice and divided into two groups. Out of two IR-injured groups, one group received intranasal administration of MESC-exo(cur) for 7 days. Similarly, two sham groups were made and one group received MESC-exo(cur) treatment. The study determined that MESC-exo(cur) treatment reduced neurological score, infarct volume and edema following IR-injury. As compared to untreated IR group, MESC-exo(cur) treated-IR group showed reduced inflammation and N-methyl-D-aspartate receptor expression. Treatment of MESC-exo(cur) also reduced astrocytic GFAP expression and alleviated the expression of NeuN positive neurons in IR-injured mice. In addition, MESC-exocur treatment restored vascular endothelial tight (claudin-5 and occludin) and adherent (VE-cadherin) junction proteins in IR-injured mice as compared to untreated IR-injured mice. These results suggest that combining the potentials of embryonic stem cell exosomes and curcumin can help neurovascular restoration following ischemia-reperfusion injury in mice. (C) 2016 Elsevier Ltd. All rights reserved.
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